Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13975421 | 0.98 | TLR8 (0.49) | TLR8ALDH1A1POLBKMT2ADRD2 | |
| SCHEMBL13965757 | 0.80 | DRD2 (0.45) | TLR8ALDH1A1POLBKMT2ADRD2 | |
| SCHEMBL5107196 | 0.80 | DRD2 (0.39) | TLR8DRD2DRD3MAPT | |
| SCHEMBL10070297 | 0.79 | — | — | |
| SCHEMBL24843680 | 0.71 | ESR1 (0.51) | ALDH1A1POLBKMT2ASMN1; SMN2LMNA | |
| SCHEMBL10540541 | 0.71 | TLR8 (0.42) | TLR8ALDH1A1POLBKMT2AHTT | |
| SCHEMBL10824919 | 0.71 | HTT (0.54) | TLR8ALDH1A1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL2495415 | 0.70 | TP53 (0.45) | ALDH1A1POLBKMT2ASMN1; SMN2LMNA | |
| SCHEMBL9963192 | 0.70 | BRD4 (0.40) | ALDH1A1POLBDRD2DRD3SMN1; SMN2 | |
| SCHEMBL1567707 | 0.70 | HTT (0.51) | TLR8HTTSMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882026-A4 | PROCESS FOR MAKING DIHYDROPYRIMIDINONES | MERCK & CO INC (US) | 1999-04-07 | — | — | EP | disclosed |
| CN-1204325-A | Process for making dihydropyrimidinones | MERCK & CO INC (US) | 1999-01-06 | — | — | CN | disclosed |
| EP-0882026-A1 | PROCESS FOR MAKING DIHYDROPYRIMIDINONES | Merck & Co., Inc. (a New Jersey corp.) (US) | 1998-12-09 | — | — | EP | disclosed |
| US-5786472-A | CATALYTIC CONDENSATION OF UREA WITH DIKETONES USIN BORON REAGENT AND ACID CATALYST | MERCK & CO., INC. (US) | 1998-07-28 | — | — | US | disclosed |
| WO-1997021687-A1 | PROCESS FOR MAKING DIHYDROPYRIMIDINONES | MERCK & CO., INC. (US) | 1997-06-19 | — | — | WO | disclosed |
| EP-0011693-A1 | N-trifluoromethane-sulfonylaminophenyl-substituted N-heterocycles, their preparation, compositions containing them and their use in regulating plant growth | CIBA-GEIGY AG (CH) | 1980-06-11 | — | — | EP | disclosed |