Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 6/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1375048 | 0.86 | KDM4E (0.53) | ALDH1A1HSD17B10TSHRL3MBTL1LMNA | |
| SCHEMBL11179013 | 0.82 | ALDH1A1 (0.55) | ALDH1A1HSD17B10TSHRL3MBTL1TDP1 | |
| SCHEMBL27519990 | 0.81 | ALDH1A1 (0.56) | ALDH1A1HSD17B10TSHRL3MBTL1TDP1 | |
| SCHEMBL125591 | 0.79 | TUBB4A (0.53) | ALDH1A1HSD17B10LMNAPDE4DKDM4E | |
| SCHEMBL27459666 | 0.75 | ALDH1A1 (0.49) | ALDH1A1HSD17B10TSHRL3MBTL1TDP1 | |
| SCHEMBL11169789 | 0.74 | ALDH1A1 (0.55) | ALDH1A1HSD17B10TSHRL3MBTL1TDP1 | |
| SCHEMBL5265221 | 0.73 | ALDH1A1 (0.53) | ALDH1A1HSD17B10TSHRL3MBTL1TDP1 | |
| SCHEMBL27487328 | 0.73 | ALDH1A1 (0.50) | ALDH1A1HSD17B10TSHRL3MBTL1TDP1 | |
| SCHEMBL2595579 | 0.72 | ALDH1A1 (0.64) | ALDH1A1HSD17B10TSHRL3MBTL1TDP1 | |
| SCHEMBL167782 | 0.72 | KDM4E (0.47) | ALDH1A1HSD17B10LMNACYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118236-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-05-19 | — | — | US | disclosed |
| EP-2269990-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118236-A1 | HETEROCYCLIC COMPOUND | GRIN1, GRM1, GRIK1 | ALDH1A1 614/4885HSD17B10 2980/4885TSHR 134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.