Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TET2 | Q6N021 | 3/20 | 0.46 |
| ▸ | KDM4A | O75164 | 2/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.46 |
| ▸ | TET3 | O43151 | 1/20 | 0.46 |
| ▸ | GABRP | O00591 | 2/20 | 0.44 |
| ▸ | GABRD | O14764 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.44 |
| ▸ | GABRE | P78334 | 2/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.44 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.44 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16600326 | 0.90 | TET2 (0.50) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL16600592 | 0.86 | PDE4A (0.48) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL3687001 | 0.81 | PDE4A (0.54) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL26138094 | 0.81 | FOLH1 (0.48) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL16600086 | 0.81 | SLC22A6 (0.42) | FOLH1GPR84LMNA | |
| SCHEMBL28908459 | 0.79 | PDE4A (0.52) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL10599631 | 0.79 | TET2 (0.60) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL15484277 | 0.79 | THRB (0.44) | LMNA | |
| SCHEMBL16600318 | 0.76 | GABRP (0.50) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL26138074 | 0.76 | TET2 (0.52) | TET2KDM4AKDM4CKDM2ATET3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093410-B2 | Intermediates and methods for the synthesis of halichondrin B analogs | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-01-10 | — | — | US | disclosed |
| US-20090198074-A1 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | EISAI CO., LTD. (JP) | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090198074-A1 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | DHPS, LSS, BMP2 | TET2 2765/4885KDM4A 4303/4885KDM4C 3839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.