Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTR1E | P28566 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709219 | 0.84 | SCN9A (0.74) | SCN9AALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL1286845 | 0.82 | SCN9A (0.66) | SCN9AALDH1A1KMT2ALMNADRD4 | |
| SCHEMBL10072037 | 0.80 | SCN9A (0.62) | SCN9AALDH1A1MAPTKMT2ADRD4 | |
| SCHEMBL10072166 | 0.80 | SCN9A (0.60) | SCN9AALDH1A1KMT2ADRD4MMP3 | |
| SCHEMBL1709255 | 0.79 | SCN9A (0.57) | SCN9AALDH1A1RAB9AMAPTKMT2A | |
| SCHEMBL10072167 | 0.79 | SCN9A (0.61) | SCN9AALDH1A1KMT2ADRD4POLB | |
| SCHEMBL1709222 | 0.78 | SCN9A (0.60) | SCN9AALDH1A1KMT2ALMNADRD4 | |
| SCHEMBL10072168 | 0.77 | SCN9A (0.56) | SCN9AALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL1709220 | 0.76 | SCN9A (0.55) | SCN9AKMT2ADRD4 | |
| SCHEMBL1709207 | 0.74 | SCN9A (0.54) | SCN9AALDH1A1KMT2ALMNADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |