Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 5/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10072037 | 0.86 | SCN9A (0.62) | SCN9AKMT2ADRD4MITF | |
| SCHEMBL10072167 | 0.83 | SCN9A (0.61) | SCN9AKMT2ADRD4MITF | |
| SCHEMBL1709219 | 0.82 | SCN9A (0.74) | SCN9AKMT2ADRD4MITF | |
| SCHEMBL1709222 | 0.82 | SCN9A (0.60) | SCN9AKMT2ADRD4 | |
| SCHEMBL1286845 | 0.81 | SCN9A (0.66) | SCN9AKMT2ADRD4MITF | |
| SCHEMBL10072168 | 0.80 | SCN9A (0.56) | SCN9AKMT2ADRD4 | |
| SCHEMBL10072166 | 0.78 | SCN9A (0.60) | SCN9AKMT2ADRD4MITF | |
| SCHEMBL10072036 | 0.76 | SCN9A (0.55) | SCN9AKMT2ADRD4 | |
| SCHEMBL1709255 | 0.74 | SCN9A (0.57) | SCN9AKMT2A | |
| SCHEMBL1286816 | 0.73 | DRD4 (0.62) | SCN9ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |