Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | TNKS | O95271 | 2/20 | 0.67 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.67 |
| ▸ | PARP1 | P09874 | 1/20 | 0.67 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10073049 | 0.85 | ALDH1A1 (0.67) | ALDH1A1KDM4ELMNAKMT2AMEN1 | |
| SCHEMBL10073031 | 0.85 | LMNA (1.00) | ALDH1A1KDM4ELMNAPOLBSMN1; SMN2 | |
| SCHEMBL1896657 | 0.81 | TNKS (1.00) | ALDH1A1LMNATNKSTNKS2PARP1 | |
| SCHEMBL15057522 | 0.78 | TNKS (0.78) | ALDH1A1LMNATNKSTNKS2PARP1 | |
| SCHEMBL16462872 | 0.78 | P2RX7 (1.00) | ALDH1A1LMNAP2RX7POLBKMT2A | |
| SCHEMBL15057674 | 0.77 | TNKS (1.00) | ALDH1A1KDM4ELMNATNKSTNKS2 | |
| SCHEMBL15057831 | 0.77 | TNKS (0.75) | ALDH1A1KDM4ELMNATNKSTNKS2 | |
| SCHEMBL15075079 | 0.77 | TNKS (0.73) | ALDH1A1LMNATNKSTNKS2PARP1 | |
| SCHEMBL27254013 | 0.77 | TNKS (0.85) | ALDH1A1LMNATNKSTNKS2PARP1 | |
| SCHEMBL16462588 | 0.76 | P2RX7 (1.00) | ALDH1A1LMNAP2RX7POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130012536-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-10 | — | — | US | disclosed |
| US-20130012536-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-10 | — | — | US | disclosed |
| US-20120035179-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED | 2012-02-09 | — | — | US | disclosed |
| US-20100125090-A1 | Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-20 | — | — | US | disclosed |
| US-20100125090-A1 | Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-20 | — | — | US | disclosed |
| US-7598412-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-10-06 | — | — | US | disclosed |
| US-7598412-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012536-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | ABCB11, ABCB1, ABCC5 | ALDH1A1 895/4885KDM4E 4529/4885LMNA 1873/4885 |
| US-20100125090-A1 | Modulators of ATP-Binding Cassette Transporters | ABCB11, ABCB1, ABCC5 | ALDH1A1 895/4885KDM4E 4529/4885LMNA 1873/4885 |
| US-20120035179-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | ABCB11, ABCB1, ABCC5 | ALDH1A1 895/4885KDM4E 4529/4885LMNA 1873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.