Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | SPR | P35270 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2730627 | 0.87 | SPR (0.49) | ALDH1A1SPRHPGDHSD17B10TSHR | |
| SCHEMBL18858805 | 0.86 | HPGD (0.46) | ALDH1A1NAMPTHPGDTSHRKDM4E | |
| SCHEMBL25122848 | 0.83 | MEN1 (0.44) | ALDH1A1NAMPTSPRHPGDHSD17B10 | |
| SCHEMBL4692525 | 0.83 | MCL1 (0.47) | ALDH1A1NAMPTSPRHPGDHSD17B10 | |
| SCHEMBL24607163 | 0.83 | MEN1 (0.56) | ALDH1A1SPRHPGDHSD17B10TSHR | |
| SCHEMBL15888695 | 0.82 | ALDH1A1 (0.47) | ALDH1A1SPRHPGDMAPTHSD17B10 | |
| SCHEMBL22856422 | 0.82 | ALDH1A1 (0.47) | ALDH1A1SPRHPGDMAPTHSD17B10 | |
| SCHEMBL15888693 | 0.82 | ALDH1A1 (0.61) | ALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL13492947 | 0.82 | NAMPT (0.41) | ALDH1A1NAMPTSPRHPGDHSD17B10 | |
| SCHEMBL14307931 | 0.81 | RAB9A (0.44) | ALDH1A1NAMPTSPRHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120309801-A1 | CALIXARENE-BASED PEPTIDE CONFORMATION MIMETICS, METHODS OF USE, AND METHODS OF MAKING | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2012-12-06 | — | — | US | disclosed |
| US-8207228-B2 | Calixarene-based peptide conformation mimetics, methods of use, and methods of making | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2012-06-26 | — | — | US | disclosed |
| US-20080300164-A1 | Calixarene-Based Peptide Conformation Mimetics, Methods of Use, and Methods of Making | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2008-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300164-A1 | Calixarene-Based Peptide Conformation Mimetics, Methods of Use, and Methods of Making | CLSPN, BID, CALU | ALDH1A1 4794/4885NAMPT 2853/4885SPR 750/4885 |
| US-20120309801-A1 | CALIXARENE-BASED PEPTIDE CONFORMATION MIMETICS, METHODS OF USE, AND METHODS OF MAKING | CLSPN, BID, CALU | ALDH1A1 4794/4885NAMPT 2853/4885SPR 750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.