SCHEMBL10073749

SCHEMBL10073749

COc1ccc(Nc2nc(Nc3cc(C)cc(C)c3)nc(Nc3cc(C)cc(C)c3)n2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.65
MEN1 O00255 4/20 0.65
KMT2A Q03164 4/20 0.65
SMN1; SMN2 Q16637 2/20 0.65
GAA P10253 2/20 0.65
L3MBTL1 Q9Y468 2/20 0.65
KCNH3 Q9ULD8 3/20 0.59
PDE4B Q07343 1/20 0.54
PDE4D Q08499 1/20 0.54
NPC1 O15118 3/20 0.54
MAPK1 P28482 3/20 0.54
RAB9A P51151 3/20 0.54
ALDH1A1 P00352 3/20 0.54
TP53 P04637 2/20 0.54
APP P05067 1/20 0.54
KDM4E B2RXH2 1/20 0.53
THRB P10828 1/20 0.53
RECQL P46063 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
TDP1 Q9NUW8 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4544853 0.87 MAPT (0.71) MAPTMEN1KMT2ASMN1; SMN2GAA
SCHEMBL13983094 0.87 MAPT (0.71) MAPTMEN1KMT2ASMN1; SMN2GAA
SCHEMBL11812041 0.87 MAPT (0.81) MAPTMEN1KMT2ASMN1; SMN2GAA
SCHEMBL824521 0.85 MAPT (0.59) MAPTMEN1KMT2ASMN1; SMN2GAA
SCHEMBL4544846 0.85 MAPT (0.59) MAPTMEN1KMT2ASMN1; SMN2GAA
SCHEMBL4544867 0.83 MAPT (0.56) MAPTMEN1KMT2ASMN1; SMN2GAA
SCHEMBL7565070 0.82 MAPT (0.64) MAPTMEN1KMT2ASMN1; SMN2GAA
SCHEMBL12732285 0.81 KCNH3 (0.68) MAPTMEN1KMT2ASMN1; SMN2GAA
SCHEMBL12895793 0.81 RAPGEF4 (0.52) MAPTSMN1; SMN2KCNH3NPC1RAB9A
SCHEMBL10099686 0.80 KCNH3 (0.77) MAPTMEN1KMT2ASMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120231217-A1 OPTICAL FILM, PHASE DIFFERENCE FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY DEVICE FUJIFILM CORPORATION (JP) 2012-09-13 US disclosed
US-20120018685-A1 Optical film, retardation film, polarizing plate, and liquid crystal display device FUJIFILM CORPORATION (JP) 2012-01-26 US disclosed