Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CHRND | Q07001 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10074530 | 0.89 | HCAR3 (0.37) | HCAR3HCAR2KMT2AMEN1PKM | |
| SCHEMBL10074531 | 0.85 | BACE1 (0.36) | HCAR3HCAR2KMT2AMEN1PKM | |
| SCHEMBL8244815 | 0.82 | PGR (0.35) | PKM | |
| SCHEMBL8247352 | 0.81 | BACE1 (0.48) | MAOB | |
| SCHEMBL10074533 | 0.81 | BACE1 (0.42) | HSD11B1 | |
| SCHEMBL8244505 | 0.80 | BACE1 (0.43) | — | |
| SCHEMBL8238800 | 0.79 | NR1H2 (0.37) | HCAR3HCAR2 | |
| SCHEMBL10084447 | 0.78 | BACE1 (0.48) | — | |
| SCHEMBL10074532 | 0.78 | BACE1 (0.34) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7539840 | 0.77 | KMT2A (0.46) | HCAR3HCAR2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110682-B2 | Preparation and use of compounds as aspartyl protease inhibitors | SCHERING CORPORATION (US) | 2012-02-07 | — | — | US | disclosed |
| US-8110682-B2 | Preparation and use of compounds as aspartyl protease inhibitors | SCHERING CORPORATION (US) | 2012-02-07 | — | — | US | disclosed |
| US-20070010667-A1 | Preparation and use of compounds as aspartyl protease inhibitors | SCHERING CORPORATION | 2007-01-11 | — | — | US | disclosed |
| US-20070010667-A1 | Preparation and use of compounds as aspartyl protease inhibitors | SCHERING CORPORATION | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010667-A1 | Preparation and use of compounds as aspartyl protease inhibitors | PRSS1, CTSS, CTSL | HCAR3 3420/4885HCAR2 4340/4885KMT2A 4664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.