Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30945860 | 0.80 | ALDH1A1 (0.61) | MEN1KMT2AMAPTTDP1MAPK1 | |
| SCHEMBL11014192 | 0.79 | MEN1 (0.71) | MEN1KMT2AATMMAPTTDP1 | |
| SCHEMBL843371 | 0.78 | CHRM2 (0.69) | MEN1KMT2AATMTDP1GAA | |
| SCHEMBL12976485 | 0.78 | KMT2A (0.70) | MEN1KMT2AATMMAPTMAPK1 | |
| SCHEMBL31547203 | 0.78 | MEN1 (0.70) | MEN1KMT2AATMMAPTTDP1 | |
| SCHEMBL6417366 | 0.78 | MEN1 (1.00) | MEN1KMT2AATMTDP1GAA | |
| SCHEMBL16523598 | 0.78 | KMT2A (0.70) | MEN1KMT2AATMMAPTTDP1 | |
| SCHEMBL16523593 | 0.78 | KMT2A (0.70) | MEN1KMT2AATMMAPTGAA | |
| SCHEMBL16980540 | 0.77 | MEN1 (0.64) | MEN1KMT2AATMMAPTMAPK1 | |
| SCHEMBL17080774 | 0.77 | MEN1 (0.64) | MEN1KMT2AATMMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012016133-A2 | ROS1 KINASE INHIBITORS FOR THE TREATMENT OF GLIOBLASTOMA AND OTHER P53-DEFICIENT CANCERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-02-02 | — | — | WO | disclosed |