Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.45 |
| ▸ | HTR2A | P28223 | 4/20 | 0.45 |
| ▸ | HTR2B | P41595 | 4/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.37 |
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10078704 | 0.74 | CYP8B1 (0.43) | CYP8B1 | |
| SCHEMBL1222623 | 0.73 | NCF1 (0.57) | HTR2CHTR2ACHRNB2CHRNA4CYP8B1 | |
| SCHEMBL4068537 | 0.72 | CYP8B1 (0.41) | CYP8B1KCNH2 | |
| SCHEMBL1224945 | 0.72 | CHRNB2 (0.56) | MAP4K1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL1222834 | 0.72 | CYP2C19 (0.46) | CYP8B1KCNH2 | |
| SCHEMBL16986059 | 0.71 | CHRNB2 (0.43) | CHRNB2CHRNB4CHRNA3CHRNA4CYP8B1 | |
| SCHEMBL4054846 | 0.70 | KCNH2 (0.36) | CYP8B1KCNH2 | |
| SCHEMBL3636416 | 0.70 | CYP2C19 (0.54) | CYP8B1KCNH2 | |
| SCHEMBL1223241 | 0.70 | CHRNB2 (0.53) | HTR2CHTR2AHTR2BCHRNB2CHRNA4 | |
| SCHEMBL1222688 | 0.70 | CYP2C19 (0.54) | CYP8B1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2915813-A1 | Oxazolidinone antibiotics | Actelion Pharmaceuticals Ltd. (CH) | 2015-09-09 | — | — | EP | disclosed |
| EP-2905283-A1 | Oxazolidinone antibiotics | Actelion Pharmaceuticals Ltd. (CH) | 2015-08-12 | — | — | EP | disclosed |
| US-8217029-B2 | Oxazolidinone antibiotics | ACTELION PHARMACEUTICALS LTD (CH) | 2012-07-10 | — | — | US | disclosed |