Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.48 |
| ▸ | LGMN | Q99538 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL868893 | 0.94 | ALDH1A1 (0.60) | KDM4EUSP2HPGDNPSR1HSD17B10 | |
| SCHEMBL10055318 | 0.88 | ALDH1A1 (0.55) | KDM4EHSD17B10ALDH1A1MAPTMEN1 | |
| SCHEMBL2264334 | 0.87 | MAPT (0.57) | KDM4EUSP2HPGDNPSR1HSD17B10 | |
| SCHEMBL21679495 | 0.84 | PTPN11 (0.53) | KDM4EUSP2HPGDNPSR1HSD17B10 | |
| SCHEMBL725443 | 0.82 | KDM4E (0.71) | KDM4EUSP2HPGDNPSR1HSD17B10 | |
| SCHEMBL195417 | 0.79 | KDM4E (0.60) | KDM4EHPGDNPSR1HSD17B10ALDH1A1 | |
| SCHEMBL8485910 | 0.79 | PPM1B (0.55) | KDM4ENPSR1ALDH1A1MAPTMEN1 | |
| SCHEMBL1296409 | 0.79 | PPM1B (0.55) | KDM4ENPSR1ALDH1A1MAPTMEN1 | |
| SCHEMBL12644983 | 0.78 | KDM4E (0.71) | KDM4EUSP2HPGDNPSR1HSD17B10 | |
| SCHEMBL724405 | 0.78 | ALDH1A1 (0.54) | KDM4EHSD17B10ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077189-A1 | SCAFFOLD-BASED POLYMERASE ENZYME SUBSTRATES | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077189-A1 | SCAFFOLD-BASED POLYMERASE ENZYME SUBSTRATES | POLM, RNGTT, POLR1G | KDM4E 2818/4885USP2 3418/4885HPGD 2802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.