Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | CA9 | Q16790 | 2/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA6 | P23280 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.52 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.49 |
| ▸ | FASN | P49327 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30497947 | 0.81 | CA12 (0.59) | CA12CA2CA9CA1CA6 | |
| SCHEMBL108054 | 0.81 | CA12 (0.59) | CA12CA2CA9CA1CA6 | |
| SCHEMBL30517873 | 0.79 | GSK3B (0.59) | CA12CA2CA9CA1CA6 | |
| SCHEMBL13305139 | 0.79 | CA12 (0.57) | CA12CA2CA9CA1CA6 | |
| SCHEMBL30408859 | 0.79 | ALDH1A1 (0.59) | CA12CA2CA9CA1CA6 | |
| SCHEMBL1361623 | 0.79 | GSK3B (0.59) | CA12CA2CA9CA1CA6 | |
| SCHEMBL2178782 | 0.79 | PARP1 (0.61) | CA12CA2CA9CA1CA6 | |
| SCHEMBL620024 | 0.79 | ALDH1A1 (0.59) | CA12CA2CA9CA1CA6 | |
| SCHEMBL79656 | 0.79 | CA12 (0.57) | CA12CA2CA9CA1CA6 | |
| SCHEMBL6398443 | 0.79 | CA12 (0.57) | CA12CA2CA9CA1CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8303935-B2 | Alkoxy substituted imidazo[1,2-a]pyridines having affinity for amyloid | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2012-11-06 | — | — | US | disclosed |
| US-20120271053-A1 | NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2012-10-25 | — | — | US | disclosed |
| US-8207189-B2 | Compound having affinity for amyloid | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2012-06-26 | — | — | US | disclosed |
| US-20100069640-A1 | NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID | NIHON MEDI-PHYSICS COL, LTD. (JP) | 2010-03-18 | — | — | US | disclosed |
| WO-2010011964-A2 | IMAGING AGENTS USEFUL FOR IDENTIFYING AD PATHOLOGY | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2010-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069640-A1 | NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID | APP, APBA1, C1QBP | CA12 357/4885CA2 662/4885CA9 830/4885 |
| US-20120271053-A1 | NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID | APBA1, SAAL1, SLC43A1 | CA12 1940/4885CA2 2231/4885CA9 2182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.