Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.32 |
| ▸ | ABAT | P80404 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359792 | 0.87 | PDE4B (0.49) | PDE4BPTPN1ALDH1A1KDM4ETSHR | |
| SCHEMBL667201 | 0.83 | ALDH1A1 (0.54) | PDE4BPTPN1ALDH1A1KDM4ETSHR | |
| SCHEMBL998425 | 0.83 | PDE4B (0.59) | PDE4BPTPN1ALDH1A1TSHRALDH1A3 | |
| SCHEMBL7802721 | 0.81 | PTPN1 (0.37) | PDE4BPTPN1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL3362970 | 0.81 | PDE4B (0.42) | PDE4BPTPN1ALDH1A1KDM4EALDH1A3 | |
| SCHEMBL5863923 | 0.81 | PDE4B (0.47) | PDE4BPTPN1ALDH1A1KDM4ETSHR | |
| SCHEMBL1755976 | 0.80 | HSD11B1 (0.41) | PDE4BPTPN1NPC1RAB9AMEN1 | |
| SCHEMBL12831493 | 0.79 | PTPN1 (0.39) | PDE4BPTPN1NPC1RAB9AMEN1 | |
| SCHEMBL5166212 | 0.79 | PTPN1 (0.38) | PDE4BPTPN1MEN1KMT2A | |
| SCHEMBL2780758 | 0.79 | L3MBTL1 (0.42) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148415-B2 | Sulfamic acid ester compounds useful in the inhibition of steroid sulphatase activity and aromatase activity | STERIX LIMITED (GB) | 2012-04-03 | — | — | US | disclosed |