Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 1/20 | 0.61 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 5/20 | 0.57 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.56 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.54 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852083 | 0.90 | MEN1 (0.56) | LTB4RLTB4R2MAOBALDH1A1NR1H4 | |
| SCHEMBL1137350 | 0.90 | ALDH1A1 (0.67) | LTB4RLTB4R2MAOBNR4A2CYP4F2 | |
| SCHEMBL1009050 | 0.89 | MAOB (0.51) | LTB4RLTB4R2MAOBALDH1A1KDM4E | |
| SCHEMBL9270474 | 0.88 | MAOB (0.59) | LTB4RLTB4R2MAOBPPARGPPARA | |
| SCHEMBL31285834 | 0.88 | PPARA (0.57) | LTB4RLTB4R2MAOBALDH1A1KDM4E | |
| SCHEMBL2008583 | 0.88 | PPARA (0.57) | LTB4RLTB4R2MAOBALDH1A1KDM4E | |
| SCHEMBL1010327 | 0.86 | SLC22A12 (0.50) | LTB4RLTB4R2MAOBL3MBTL1MAPK1 | |
| SCHEMBL10733098 | 0.86 | FFAR1 (0.60) | LTB4RLTB4R2MAOBNR4A2CYP4F2 | |
| SCHEMBL8051693 | 0.86 | NR1H4 (0.51) | LTB4RLTB4R2MAOBALDH1A1NR1H4 | |
| SCHEMBL4209383 | 0.86 | CYSLTR2 (0.54) | LTB4RLTB4R2ALDH1A1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3517109-A1 | COMPOUNDS AND METHOD FOR REDUCING URIC ACID | Wellstat Therapeutics Corporation (US) | 2019-07-31 | — | — | EP | disclosed |
| EP-2268141-B1 | COMPOUND AND METHOD FOR REDUCING URIC ACID | WELLSTAT THERAPEUTICS CORP (US) | 2019-05-08 | — | — | EP | disclosed |
| US-9115072-B2 | Compounds and method for reducing uric acid | WELLSTAT THERAPEUTICS CORPORATION (US) | 2015-08-25 | — | — | US | disclosed |
| CN-101969773-B | compounds and methods for reducing uric acid | WELLSTAT THERAPEUTICS CORP. (US) | 2015-08-19 | — | — | CN | disclosed |
| CN-102976928-B | Compounds for reducing uric acid | WELLSTAT THERAPEUTICS CORP | 2014-09-17 | — | — | CN | disclosed |
| US-8829058-B2 | Compounds and method for reducing uric acid | WELLSTAT THERAPEUTICS CORPORATION (US) | 2014-09-09 | — | — | US | disclosed |
| US-20130259850-A1 | COMPOUNDS AND METHOD FOR REDUCING URIC ACID | WELLSTAT THERAPEUTICS CORPORATION (US) | 2013-10-03 | — | — | US | disclosed |
| CN-103044254-A | 2,4-dyhydroxy-6-substituted-phenyl aliphatic ketone derivatives and application thereof | UNIV SHANDONG | 2013-04-17 | — | — | CN | disclosed |
| CN-102976928-A | Compounds for reducing uric acid | WELLSTAT THERAPEUTICS CORP | 2013-03-20 | — | — | CN | disclosed |
| CN-101969773-A | compounds and methods for reducing uric acid | WELLSTAT THERAPEUTICS CORP | 2011-02-09 | — | — | CN | disclosed |
| EP-2268141-A1 | COMPOUNDS AND METHOD FOR REDUCING URIC ACID | Wellstat Therapeutics Corporation (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009151695-A1 | COMPOUNDS AND METHOD FOR REDUCING URIC ACID | WELLSTAT THERAPEUTICS CORPORATION (US) | 2009-12-17 | — | — | WO | disclosed |
| CN-100345850-C | 3-phenyl-substituted pyridoindolones, their preparation and therapeutic use | SANOFI AVENTIS (FR) | 2007-10-31 | — | — | CN | disclosed |
| CN-1729190-A | 3-phenyl-substituted pyridoindolones, their preparation and therapeutic use | SANOFI AVENTIS (FR) | 2006-02-01 | — | — | CN | disclosed |
| CN-1093536-C | 5-lipoxygenase inhibitors | PFIZER (US) | 2002-10-30 | — | — | CN | disclosed |
| CN-1169722-A | 5-lipoxygenase inhibitors | PFIZER (US) | 1998-01-07 | — | — | CN | disclosed |
| EP-0462830-B1 | Cyclic ether derivatives | ZENECA LTD (GB) | 1995-10-18 | — | — | EP | disclosed |
| US-5407945-A | Pyran derivatives and their use as inhibitors of 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES, INC. (GB) | 1995-04-18 | — | — | US | disclosed |
| US-5254581-A | Used in the treatment of various inflammatory and allergic diseases | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-19 | — | — | US | disclosed |
| EP-0462830-A2 | Cyclic ether derivatives | ZENECA LIMITED (GB) | 1991-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130259850-A1 | COMPOUNDS AND METHOD FOR REDUCING URIC ACID | RCC2, HAX1, SLC10A6 | LTB4R 2713/4885LTB4R2 2714/4885MAOB 3406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.