Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.62 |
| ▸ | ILK | Q13418 | 1/20 | 0.59 |
| ▸ | KDM1A | O60341 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 5/20 | 0.56 |
| ▸ | FLT1 | P17948 | 2/20 | 0.56 |
| ▸ | RET | P07949 | 2/20 | 0.54 |
| ▸ | KIF5B | P33176 | 2/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | FLT4 | P35916 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994526 | 0.89 | EGFR (0.69) | EGFRKDRERBB2HDAC3HDAC4 | |
| SCHEMBL10080593 | 0.89 | FBP1 (0.65) | EGFRKDRRETKIF5BERBB2 | |
| SCHEMBL12846249 | 0.88 | EGFR (0.64) | EGFRKDRFLT1RETKIF5B | |
| SCHEMBL18176217 | 0.86 | EGFR (0.62) | EGFRILKKDM1AKDRERBB2 | |
| SCHEMBL17538489 | 0.84 | EGFR (0.68) | EGFRKDRERBB2HDAC3HDAC4 | |
| SCHEMBL9911558 | 0.84 | EGFR (0.61) | EGFRKDRFLT1ERBB2HDAC3 | |
| Hydrochloric Acid SCHEMBL18979162 | 0.83 | EGFR (0.67) | EGFRKDRERBB2HDAC3HDAC4 | |
| SCHEMBL25707230 | 0.82 | RET (0.68) | EGFRKDRRETKIF5BERBB2 | |
| SCHEMBL8213639 | 0.81 | HDAC3 (0.77) | EGFRKDRERBB2HDAC3HDAC4 | |
| SCHEMBL25735856 | 0.81 | RET (0.55) | EGFRKDRRETKIF5BERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165352-A1 | 6-AMINO QUINAZOLINE OR 3-CYANO QUINOLINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165352-A1 | 6-AMINO QUINAZOLINE OR 3-CYANO QUINOLINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | CSNK1G3, CSNK1A1, CSNK1A1L | EGFR 3299/4885ILK 3598/4885KDM1A 4208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.