Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGALS9 | O00182 | 1/20 | 0.43 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.43 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.43 |
| ▸ | LGALS7; LGALS7B | P47929 | 1/20 | 0.43 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 8/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19326490 | 1.00 | LGALS9 (0.43) | LGALS9LGALS1LGALS3LGALS7; LGALS7BRNASE1 | |
| SCHEMBL475965 | 1.00 | LGALS9 (0.43) | LGALS9LGALS1LGALS3LGALS7; LGALS7BRNASE1 | |
| SCHEMBL14769872 | 0.90 | KMT2A (0.40) | LGALS9LGALS1LGALS3LGALS7; LGALS7BGAA | |
| SCHEMBL13151599 | 0.88 | ALDH1A1 (0.47) | GAAKMT2ANPSR1MAPTHTT | |
| SCHEMBL15117573 | 0.88 | ALDH1A1 (0.47) | GAAKMT2ANPSR1MAPTHTT | |
| SCHEMBL475953 | 0.88 | ALDH1A1 (0.47) | GAAKMT2ANPSR1MAPTHTT | |
| SCHEMBL14473769 | 0.88 | ALDH1A1 (0.47) | GAAKMT2ANPSR1MAPTHTT | |
| SCHEMBL12481647 | 0.88 | ALDH1A1 (0.47) | GAAKMT2ANPSR1MAPTHTT | |
| SCHEMBL12355575 | 0.87 | LGALS9 (0.44) | LGALS9LGALS1LGALS3LGALS7; LGALS7BRNASE1 | |
| SCHEMBL12355573 | 0.87 | LGALS9 (0.44) | LGALS9LGALS1LGALS3LGALS7; LGALS7BRNASE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492539-B2 | Preparation of 2′-fluoro-2′-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives | GILEAD PHARMASSET LLC (US) | 2013-07-23 | — | — | US | disclosed |
| US-8481713-B2 | Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidines and purines and their derivatives | GILEAD PHARMASSET LLC (US) | 2013-07-09 | — | — | US | disclosed |
| US-8481713-B2 | Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidines and purines and their derivatives | GILEAD PHARMASSET LLC (US) | 2013-07-09 | — | — | US | disclosed |
| EP-1773856-B1 | PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | PHARMASSET INC (US) | 2012-02-01 | — | — | EP | disclosed |
| US-20100234585-A1 | PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | PHARMASSET, INC. (US) | 2010-09-16 | — | — | US | disclosed |
| US-20100234585-A1 | PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | PHARMASSET, INC. (US) | 2010-09-16 | — | — | US | disclosed |
| US-20100048917-A1 | PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | PHARMASSETT, INC. (US) | 2010-02-25 | — | — | US | disclosed |
| US-7601820-B2 | Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidines and purines and their derivatives | PHARMASSET, INC. (US) | 2009-10-13 | — | — | US | disclosed |
| US-7601820-B2 | Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidines and purines and their derivatives | PHARMASSET, INC. (US) | 2009-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048917-A1 | PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | NSUN2, FBL, UMPS | LGALS9 2175/4885LGALS1 1873/4885LGALS3 1938/4885 |
| US-20100234585-A1 | PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | NSUN2, FBL, UMPS | LGALS9 2175/4885LGALS1 1873/4885LGALS3 1938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.