Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGALS9 | O00182 | 1/20 | 0.44 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.44 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.44 |
| ▸ | LGALS7; LGALS7B | P47929 | 1/20 | 0.44 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12355575 | 1.00 | LGALS9 (0.44) | LGALS9LGALS1LGALS3LGALS7; LGALS7BRNASE1 | |
| SCHEMBL12355571 | 0.88 | KMT2A (0.39) | LGALS9LGALS1LGALS3LGALS7; LGALS7BRNASE1 | |
| SCHEMBL10017434 | 0.88 | KMT2A (0.39) | LGALS9LGALS1LGALS3LGALS7; LGALS7BRNASE1 | |
| SCHEMBL10081975 | 0.87 | LGALS9 (0.43) | LGALS9LGALS1LGALS3LGALS7; LGALS7BRNASE1 | |
| SCHEMBL19326490 | 0.87 | LGALS9 (0.43) | LGALS9LGALS1LGALS3LGALS7; LGALS7BRNASE1 | |
| SCHEMBL475965 | 0.87 | LGALS9 (0.43) | LGALS9LGALS1LGALS3LGALS7; LGALS7BRNASE1 | |
| SCHEMBL881734 | 0.87 | ALDH1A1 (0.44) | NPC1SMN1; SMN2POLBGAAKMT2A | |
| SCHEMBL13429626 | 0.87 | ALDH1A1 (0.44) | NPC1SMN1; SMN2POLBGAAKMT2A | |
| SCHEMBL13848168 | 0.82 | TYMP (0.35) | LGALS9LGALS1LGALS3LGALS7; LGALS7BPOLB | |
| SCHEMBL10017431 | 0.82 | TYMP (0.35) | LGALS9LGALS1LGALS3LGALS7; LGALS7BPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994310-B2 | Process for preparing 2′-deoxy-2′, 2′-difluorocytidine | DONGWOO SYNTECH CO., LTD. (KR) | 2011-08-09 | — | — | US | disclosed |
| US-20100069625-A1 | PROCESS FOR PREPARING OF 2'-DEOXY-2'2'-DIFLUOROCYTIDINE | DONGWOO SYNTECH CO., LTD (KR) | 2010-03-18 | — | — | US | disclosed |
| US-20100069625-A1 | PROCESS FOR PREPARING OF 2'-DEOXY-2'2'-DIFLUOROCYTIDINE | DONGWOO SYNTECH CO., LTD (KR) | 2010-03-18 | — | — | US | disclosed |
| US-7638642-B2 | Method for the preparation of D-erythro-2,2-difluoro-2-deoxy-1-oxoribose derivative | Hanmi Pharm, Co., Ltd (KR) | 2009-12-29 | — | — | US | disclosed |
| US-7638642-B2 | Method for the preparation of D-erythro-2,2-difluoro-2-deoxy-1-oxoribose derivative | Hanmi Pharm, Co., Ltd (KR) | 2009-12-29 | — | — | US | disclosed |
| US-20090221811-A1 | PROCESS FOR PREPARING GEMCITABINE AND ASSOCIATED INTERMEDIATES | CHEMAGIS LTD. (IL) | 2009-09-03 | — | — | US | disclosed |
| US-20090221811-A1 | PROCESS FOR PREPARING GEMCITABINE AND ASSOCIATED INTERMEDIATES | CHEMAGIS LTD. (IL) | 2009-09-03 | — | — | US | disclosed |
| US-20080262215-A1 | GEMCITABINE PRODUCTION PROCESS | CHEMAGIS LTD. (IL) | 2008-10-23 | — | — | US | disclosed |
| US-20080058509-A1 | Method for the Preparation of D-Erythro-2,2-Difluoro-2-Deoxy-1-Oxoribose Derivative | HANMI PHARM, CO., LTD. (KR) | 2008-03-06 | — | — | US | disclosed |
| US-20070249823-A1 | PROCESS FOR PREPARING GEMCITABINE AND ASSOCIATED INTERMEDIATES | CHEMAGIS LTD. (IL) | 2007-10-25 | — | — | US | disclosed |
| US-20070191598-A1 | Process for Preparing Gemcitabine and Associated Intermediates | CHEMAGIS LTD. (IL) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069625-A1 | PROCESS FOR PREPARING OF 2'-DEOXY-2'2'-DIFLUOROCYTIDINE | DPYD, DUT, DHPS | LGALS9 3835/4885LGALS1 4693/4885LGALS3 4755/4885 |
| US-20070249823-A1 | PROCESS FOR PREPARING GEMCITABINE AND ASSOCIATED INTERMEDIATES | DPYD, PARP1, PARP2 | LGALS9 1046/4885LGALS1 1515/4885LGALS3 904/4885 |
| US-20080262215-A1 | GEMCITABINE PRODUCTION PROCESS | SAMHD1, DCK, DCTD | LGALS9 956/4885LGALS1 1750/4885LGALS3 1391/4885 |
| US-20080058509-A1 | Method for the Preparation of D-Erythro-2,2-Difluoro-2-Deoxy-1-Oxoribose Derivative | DHPS, DHODH, DHFR | LGALS9 4035/4885LGALS1 4295/4885LGALS3 3158/4885 |
| US-20070191598-A1 | Process for Preparing Gemcitabine and Associated Intermediates | DCTD, DPYD, THPO | LGALS9 1692/4885LGALS1 2872/4885LGALS3 1715/4885 |
| US-20090221811-A1 | PROCESS FOR PREPARING GEMCITABINE AND ASSOCIATED INTERMEDIATES | THPO, DPYD, DCTD | LGALS9 1701/4885LGALS1 2661/4885LGALS3 1891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.