Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | MPO | P05164 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1972557 | 0.83 | ALDH1A1 (0.40) | CYP3A4MPO | |
| SCHEMBL3199071 | 0.77 | FFAR4 (0.32) | FFAR4HTR1ADRD2HTR2AMPO | |
| SCHEMBL5468578 | 0.70 | ATR (0.38) | FFAR4HTR1ADRD2HTR2AMPO | |
| SCHEMBL3756039 | 0.69 | CYP3A4 (0.46) | CYP3A4GABRA1GABRB2 | |
| SCHEMBL31135849 | 0.69 | CYP3A4 (0.46) | CYP3A4 | |
| SCHEMBL10175066 | 0.69 | CYP3A4 (0.46) | CYP3A4 | |
| SCHEMBL30677836 | 0.69 | FFAR4 (0.37) | FFAR4HTR1ADRD2HTR2AMPO | |
| SCHEMBL978248 | 0.67 | MPO (0.33) | FFAR4HTR1ADRD2HTR2AMPO | |
| SCHEMBL13551133 | 0.67 | MPO (0.33) | FFAR4HTR1ADRD2HTR2AMPO | |
| SCHEMBL334653 | 0.67 | MPO (0.39) | CYP3A4FFAR4HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2009992-B1 | IL-8 RECEPTOR ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2012-06-27 | — | — | EP | disclosed |
| US-20110105563-A1 | IL-8 RECEPTOR ANTAGONISTS | BUSCH-PETERSEN JAKOB | 2011-05-05 | — | — | US | disclosed |
| US-20110105563-A1 | IL-8 RECEPTOR ANTAGONISTS | BUSCH-PETERSEN JAKOB | 2011-05-05 | — | — | US | disclosed |
| US-20110059937-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION | 2011-03-10 | — | — | US | disclosed |
| US-20110059937-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION | 2011-03-10 | — | — | US | disclosed |
| US-7893089-B2 | IL-8 receptor antagonists | GlaxoSmithKline, LLC (US) | 2011-02-22 | — | — | US | disclosed |
| US-7893089-B2 | IL-8 receptor antagonists | GlaxoSmithKline, LLC (US) | 2011-02-22 | — | — | US | disclosed |
| US-20090298810-A1 | IL-8 Receptor Antagonists | SMITHKLINE BEECHAM CORPORATION | 2009-12-03 | — | — | US | disclosed |
| US-20090093451-A1 | IL-8 Receptor Antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-09 | — | — | US | disclosed |
| US-20090093451-A1 | IL-8 Receptor Antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-09 | — | — | US | disclosed |
| US-20070249672-A1 | IL-8 Receptor Antagonists | GLAXOSMITHKLINE LLC | 2007-10-25 | — | — | US | disclosed |
| US-20070249672-A1 | IL-8 Receptor Antagonists | GLAXOSMITHKLINE LLC | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105563-A1 | IL-8 RECEPTOR ANTAGONISTS | CXCL8, CCR8, IL1RN | CYP3A4 3211/4885FFAR4 225/4885HTR1A 1459/4885 |
| US-20070249672-A1 | IL-8 Receptor Antagonists | CXCL8, CCR8, IL1RN | CYP3A4 3211/4885FFAR4 225/4885HTR1A 1459/4885 |
| US-20110059937-A1 | IL-8 RECEPTOR ANTAGONISTS | CXCL8, CCR8, IL1RN | CYP3A4 3211/4885FFAR4 225/4885HTR1A 1459/4885 |
| US-20090298810-A1 | IL-8 Receptor Antagonists | CXCL8, CCR8, IL1RN | CYP3A4 3218/4885FFAR4 262/4885HTR1A 1472/4885 |
| US-20090093451-A1 | IL-8 Receptor Antagonists | CXCL8, CCR8, IL1RN | CYP3A4 3211/4885FFAR4 225/4885HTR1A 1459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.