Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665086 | 0.91 | TSHR (0.44) | TSHRALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL1665311 | 0.78 | TSHR (0.36) | TSHRALDH1A1MEN1KMT2ARECQL | |
| SCHEMBL12695618 | 0.77 | NOS3 (0.40) | ALDH1A1HSD17B10 | |
| SCHEMBL10085230 | 0.75 | CYP1A2 (0.41) | TSHRALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL22956016 | 0.74 | CES2 (0.42) | TSHRALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL22955375 | 0.74 | CES2 (0.42) | TSHRALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL14566406 | 0.74 | MEN1 (0.33) | ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL22500800 | 0.74 | TSHR (0.58) | TSHRALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL6891006 | 0.72 | TSHR (0.42) | TSHRALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL9883714 | 0.72 | TSHR (0.56) | TSHRALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10793884-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-10-06 | — | — | US | disclosed |
| US-10689628-B2 | Method of making variant LovD polypeptides | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-06-23 | — | — | US | disclosed |
| US-20190169580-A1 | VARIANT LovD POLYPEPTIDE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-06-06 | — | — | US | disclosed |
| US-10246689-B2 | Variant LovD polypeptide | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-04-02 | — | — | US | disclosed |
| US-9970037-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-05-15 | — | — | US | disclosed |
| US-9970037-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-05-15 | — | — | US | disclosed |
| US-20170029790-A1 | VARIANT LovD POLYPEPTIDE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-02-02 | — | — | US | disclosed |
| US-20170029790-A1 | VARIANT LovD POLYPEPTIDE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-02-02 | — | — | US | disclosed |
| US-9499803-B2 | Variant LovD polypeptide | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-22 | — | — | US | disclosed |
| US-9499803-B2 | Variant LovD polypeptide | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-22 | — | — | US | disclosed |
| US-8951754-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-02-10 | — | — | US | disclosed |
| US-20120315680-A1 | METHODS AND MATERIALS FOR MAKING SIMVASTATIN AND RELATED COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-12-13 | — | — | US | disclosed |
| US-20120315680-A1 | METHODS AND MATERIALS FOR MAKING SIMVASTATIN AND RELATED COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-12-13 | — | — | US | disclosed |
| US-20120190038-A1 | LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-26 | — | — | US | disclosed |
| US-20120190038-A1 | LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-26 | — | — | US | disclosed |
| US-8211664-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-03 | — | — | US | disclosed |
| US-8211664-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-03 | — | — | US | disclosed |
| EP-2032715-B1 | Methods and materials for making simvastatin and related compounds | UNIV CALIFORNIA (US) | 2012-02-01 | — | — | EP | disclosed |
| US-20090191602-A1 | Methods and Materials for Making Simvastatin and Related Compounds | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2009-07-30 | — | — | US | disclosed |
| US-20090191602-A1 | Methods and Materials for Making Simvastatin and Related Compounds | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2009-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170029790-A1 | VARIANT LovD POLYPEPTIDE | FNTA, PCSK9, HMGCR | TSHR 4601/4885ALDH1A1 3669/4885LMNA 3323/4885 |
| US-10246689-B2 | Variant LovD polypeptide | FNTA, HMGCR, PCSK9 | TSHR 4624/4885ALDH1A1 3650/4885LMNA 3152/4885 |
| US-20190169580-A1 | VARIANT LovD POLYPEPTIDE | FNTA, HMGCR, PCSK9 | TSHR 4624/4885ALDH1A1 3650/4885LMNA 3152/4885 |
| US-10689628-B2 | Method of making variant LovD polypeptides | FNTA, HMGCR, COASY | TSHR 4702/4885ALDH1A1 2845/4885LMNA 2727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.