Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.32 |
| ▸ | PPARG | P37231 | 6/20 | 0.32 |
| ▸ | PPARD | Q03181 | 6/20 | 0.32 |
| ▸ | PPARA | Q07869 | 6/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308703 | 0.80 | TSHR (0.48) | TSHRCYP1A2KMT2ATDP1HSD17B10 | |
| SCHEMBL1665086 | 0.80 | TSHR (0.44) | TSHRKMT2AHSD17B10LMNAALDH1A1 | |
| SCHEMBL10085230 | 0.79 | CYP1A2 (0.41) | TSHRCYP1A2KMT2ATDP1LMNA | |
| SCHEMBL12149865 | 0.78 | RIPK1 (0.31) | TDP1RIPK1 | |
| SCHEMBL13522419 | 0.77 | RIPK1 (0.31) | RIPK1 | |
| SCHEMBL12695618 | 0.77 | NOS3 (0.40) | TDP1HSD17B10ALDH1A1THRB | |
| SCHEMBL11671380 | 0.75 | ALDH1A1 (0.42) | TSHRCYP1A2ALDH1A1RIPK1 | |
| SCHEMBL22956016 | 0.73 | CES2 (0.42) | TSHRKMT2ATDP1HSD17B10ALDH1A1 | |
| SCHEMBL22955375 | 0.73 | CES2 (0.42) | TSHRKMT2ATDP1HSD17B10ALDH1A1 | |
| SCHEMBL14566406 | 0.73 | MEN1 (0.33) | CYP1A2KMT2AHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10793884-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-10-06 | — | — | US | disclosed |
| US-10689628-B2 | Method of making variant LovD polypeptides | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-06-23 | — | — | US | disclosed |
| US-20190169580-A1 | VARIANT LovD POLYPEPTIDE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-06-06 | — | — | US | disclosed |
| US-10246689-B2 | Variant LovD polypeptide | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-04-02 | — | — | US | disclosed |
| US-9970037-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-05-15 | — | — | US | disclosed |
| US-9970037-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-05-15 | — | — | US | disclosed |
| US-20170029790-A1 | VARIANT LovD POLYPEPTIDE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-02-02 | — | — | US | disclosed |
| US-20170029790-A1 | VARIANT LovD POLYPEPTIDE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-02-02 | — | — | US | disclosed |
| US-9499803-B2 | Variant LovD polypeptide | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-22 | — | — | US | disclosed |
| US-9499803-B2 | Variant LovD polypeptide | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-22 | — | — | US | disclosed |
| CN-102712678-A | Improved LOV-D acyltransferase mediated acylation | CODEXIS INC | 2012-10-03 | — | — | CN | disclosed |
| EP-2483293-A1 | IMPROVED LOV-D ACYLTRANSFERASE MEDIATED ACYLATION | Codexis, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| US-20120190038-A1 | LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-26 | — | — | US | disclosed |
| US-20120190038-A1 | LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-26 | — | — | US | disclosed |
| US-8211664-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-03 | — | — | US | disclosed |
| US-8211664-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-03 | — | — | US | disclosed |
| EP-2032715-B1 | Methods and materials for making simvastatin and related compounds | UNIV CALIFORNIA (US) | 2012-02-01 | — | — | EP | disclosed |
| WO-2011044496-A2 | LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-04-14 | — | — | WO | disclosed |
| US-20090191602-A1 | Methods and Materials for Making Simvastatin and Related Compounds | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2009-07-30 | — | — | US | disclosed |
| US-20090191602-A1 | Methods and Materials for Making Simvastatin and Related Compounds | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2009-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170029790-A1 | VARIANT LovD POLYPEPTIDE | FNTA, PCSK9, HMGCR | TSHR 4601/4885CYP1A2 2095/4885KMT2A 1901/4885 |
| US-10246689-B2 | Variant LovD polypeptide | FNTA, HMGCR, PCSK9 | TSHR 4624/4885CYP1A2 1983/4885KMT2A 1938/4885 |
| US-20190169580-A1 | VARIANT LovD POLYPEPTIDE | FNTA, HMGCR, PCSK9 | TSHR 4624/4885CYP1A2 1983/4885KMT2A 1938/4885 |
| US-10689628-B2 | Method of making variant LovD polypeptides | FNTA, HMGCR, COASY | TSHR 4702/4885CYP1A2 1705/4885KMT2A 2000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.