Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | PLK1 | P53350 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8568151 | 0.79 | PLK1 (0.47) | PLK1KMT2AJAK1TYK2ALDH1A1 | |
| SCHEMBL2652368 | 0.73 | NPC1 (0.50) | PLK1KMT2AJAK1TYK2ALDH1A1 | |
| SCHEMBL6269945 | 0.71 | PLK1 (0.46) | PLK1KMT2AALDH1A1HSD17B10HPGD | |
| SCHEMBL8582664 | 0.71 | KDM4E (0.41) | CA2KMT2ACA1CA5ACA9 | |
| SCHEMBL8578770 | 0.70 | CA2 (0.44) | CA2CA1CA5ACA9ALDH1A1 | |
| SCHEMBL6392944 | 0.69 | PLK1 (0.60) | PLK1KMT2AALDH1A1HPGDMEN1 | |
| Hydrochloric Acid SCHEMBL27655722 | 0.68 | PLK1 (0.58) | PLK1KMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL8582672 | 0.68 | CA2 (0.45) | CA2CA1CA5ACA9ALDH1A1 | |
| SCHEMBL8573287 | 0.67 | PLK1 (0.57) | PLK1KMT2AALDH1A1HSD17B10HPGD | |
| SCHEMBL11445475 | 0.67 | ALDH1A1 (0.49) | PLK1JAK1TYK2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268612-A1 | ARYLSULFONAMIDE-BASED MATRIX METALLOPROTEASE INHIBITORS | Novartis AG (CH) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009118292-A1 | ARYLSULFONAMIDE-BASED MATRIX METALLOPROTEASE INHIBITORS | NOVARTIS AG (CH) | 2009-10-01 | — | — | WO | disclosed |