Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 3/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652368 | 0.85 | NPC1 (0.50) | PLK1JAK1TYK2MTNR1AALDH1A1 | |
| SCHEMBL6392944 | 0.81 | PLK1 (0.60) | PLK1ALDH1A1HPGDMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL27655722 | 0.80 | PLK1 (0.58) | PLK1ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL6269945 | 0.80 | PLK1 (0.46) | PLK1MTNR1AALDH1A1HPGDGAA | |
| SCHEMBL1008689 | 0.79 | CA2 (0.41) | PLK1JAK1TYK2MTNR1AALDH1A1 | |
| SCHEMBL6646160 | 0.79 | TDP1 (0.52) | ALDH1A1HPGDKDM4EHSD17B10MAPT | |
| SCHEMBL6645354 | 0.77 | NNMT (0.49) | ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29276198 | 0.76 | CTSS (0.46) | PLK1MTNR1AALDH1A1HPGDKDM4E | |
| SCHEMBL28854113 | 0.75 | MAPT (0.53) | ALDH1A1HPGDKDM4EGAAHSD17B10 | |
| SCHEMBL8573287 | 0.75 | PLK1 (0.57) | PLK1ALDH1A1HPGDGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | claimed |