Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Diphenylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.63 |
| ▸ | HTR2B | P41595 | 1/20 | 0.63 |
| ▸ | SNCA | P37840 | 1/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | AR | P10275 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylamine SCHEMBL28015233 | 1.00 | HSD17B10 (0.67) | HSD17B10ALDH1A1TSHRTDP1L3MBTL1 | |
| Diphenylamine SCHEMBL1008716 | 1.00 | HSD17B10 (0.67) | HSD17B10ALDH1A1TSHRTDP1L3MBTL1 | |
| Diphenylamine SCHEMBL5145295 | 0.97 | HSD17B10 (0.63) | HSD17B10ALDH1A1TSHRTDP1L3MBTL1 | |
| Diphenylamine SCHEMBL28870226 | 0.95 | HSD17B10 (0.60) | HSD17B10ALDH1A1TSHRTDP1L3MBTL1 | |
| Diphenylamine SCHEMBL7079615 | 0.95 | HSD17B10 (0.60) | HSD17B10ALDH1A1TSHRTDP1L3MBTL1 | |
| Diphenylamine SCHEMBL1626446 | 0.91 | MAPT (0.61) | HSD17B10ALDH1A1TSHRTDP1L3MBTL1 | |
| Diphenylamine SCHEMBL5665558 | 0.90 | HSD17B10 (0.60) | HSD17B10ALDH1A1TSHRTDP1L3MBTL1 | |
| Sulfuric Acid SCHEMBL970713 | 0.87 | MAPT (0.75) | HSD17B10ALDH1A1TSHRTDP1L3MBTL1 | |
| Diphenylamine SCHEMBL9158323 | 0.85 | HSD17B10 (0.55) | HSD17B10ALDH1A1TSHRTDP1L3MBTL1 | |
| Diphenylamine SCHEMBL28417536 | 0.85 | TSHR (0.73) | HSD17B10ALDH1A1TSHRTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 197 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113646676-B | Polarizing film, polarizing plate, and method for producing polarizing film | 日东电工株式会社 | 2024-07-23 | — | — | CN | claimed |
| CN-117299134-A | Multi-metal oxide catalytic ozonation ammonia nitrogen catalyst and preparation method thereof | 中国石油化工股份有限公司 | 2023-12-29 | — | — | CN | claimed |
| CN-117247141-A | Quick-start directional embedded microbial film for MABR and application thereof | 中国科学院青岛生物能源与过程研究所 | 2023-12-19 | — | — | CN | claimed |
| CN-115144389-A | Purified water detection process in pharmaceutical engineering | 药科国信(浙江)质量技术有限公司 | 2022-10-04 | — | — | CN | claimed |
| CN-110423049-B | Early-strength anti-channeling well cementation cement slurry and preparation method thereof | 中国石油天然气股份有限公司 | 2021-11-30 | — | — | CN | claimed |
| CN-112850748-A | Preparation method of lead hexacyanoferrate | 四川蓝狮科技有限公司 | 2021-05-28 | — | — | CN | claimed |
| CN-110423049-A | Early-strength anti-channeling well cementation cement slurry and preparation method thereof | PETROCHINA CO LTD | 2019-11-08 | — | — | CN | claimed |
| CN-106770540-B | A kind of cadmium lead electrochemical sensor and preparation method thereof of N doping mesoporous carbon modification | 中国科学院新疆理化技术研究所 | 2019-02-19 | — | — | CN | claimed |
| CN-107790135-A | How Hydrogenation is for catalyst of decahydronaphthalene and its preparation method and application for a kind of tetrahydrochysene | 西南化工研究设计院有限公司 | 2018-03-13 | — | — | CN | claimed |
| CN-106770540-A | A kind of cadmium lead electrochemical sensor of N doping mesoporous carbon modification and preparation method thereof | 中国科学院新疆理化技术研究所 | 2017-05-31 | — | — | CN | claimed |
| CN-104248958-A | Low-temperature hydrocarbon steam conversion catalyst and its preparation method and use | CHINA PETROLEUM & CHEMICAL | 2014-12-31 | — | — | CN | claimed |
| CN-104248956-A | Gas-state hydrocarbon steam pre-conversion catalyst, and preparation method and application thereof | CHINA PETROLEUM & CHEMICAL | 2014-12-31 | — | — | CN | claimed |
| CN-104248957-A | Light-hydrocarbon steam pre-conversion catalyst, and preparation method and application thereof | CHINA PETROLEUM & CHEMICAL | 2014-12-31 | — | — | CN | claimed |
| CN-103480378-A | Preparation method of improved copper base catalyst for methanol synthesis | CHINA PETROLEUM & CHEMICAL | 2014-01-01 | — | — | CN | claimed |
| CN-102451695-A | Preparation method of copper-based methanol synthesis catalyst | CHINA PETROCHEMICAL CORP | 2012-05-16 | — | — | CN | claimed |
| CN-101700496-B | Catalyst for synthesizing methyl glycolate through hydrogenation by dimethyl oxalate and preparation method thereof | JIANGSU DANHUA ACETIC ACID CO LTD | 2012-03-07 | — | — | CN | claimed |
| CN-101912782-B | dual-purpose pre-conversion catalyst of gaseous hydrocarbon and liquid hydrocarbon and preparation method thereof | SW RES & DESIGN INST CHEM IND | 2011-11-23 | — | — | CN | claimed |
| CN-101912782-A | dual-purpose pre-conversion catalyst of gaseous hydrocarbon and liquid hydrocarbon and preparation method thereof | SW RES & DESIGN INST CHEM IND | 2010-12-15 | — | — | CN | claimed |
| CN-101700496-A | Catalyst for synthesizing methyl glycolate through hydrogenation by dimethyl oxalate and preparation method thereof | JIANGSU DANHUA ACETIC ACID CO | 2010-05-05 | — | — | CN | claimed |
| CN-101672789-A | Quick detection method for nitrate nitrogen on vegetables and quick detection box thereof | SHANGHAI ACAD AGRI SCIENCES | 2010-03-17 | — | — | CN | claimed |