Diphenylamine — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 CALCRL CHRM1 CHRM2 CHRM3 F2R MAOA MAOB MAP2K1 MAP2K2 NTRK1 NTRK2 NTRK3 OPRD1 OPRK1 OPRM1 P2RY12 PKLR SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SLC18A2 SLC6A2 SLC6A3 TLR7 TLR9 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 dacA dacB dacC folA ftsI mrcA mrcB mrdA pol rplA rplB rplC rplD rplE rplF rplI rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmB1 rpmB2 rpmC rpmD rpmE rpmE2 rpmF rpmG rpmG1 rpmG2 rpmH rpmI rpmJ rpmJ2 rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsR1 rpsR2 rpsS rpsT rpsU rpsZ ykgM ykgO

The experimentally established mechanism targets of Diphenylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	SLC6A2 known ✓	P23975	1/20	0.60

▸	HSD17B10	Q99714	3/20	0.63

▸	ALDH1A1	P00352	5/20	0.60

▸	TSHR	P16473	3/20	0.60

▸	TDP1	Q9NUW8	3/20	0.60

▸	L3MBTL1	Q9Y468	3/20	0.60

▸	ALOX12	P18054	2/20	0.60

▸	ALOX15	P16050	1/20	0.60

▸	PTGS1	P23219	1/20	0.60

▸	MAPK1	P28482	1/20	0.60

▸	PTGS2	P35354	1/20	0.60

▸	HTR2B	P41595	1/20	0.60

▸	SNCA	P37840	1/20	0.55

▸	CASP3	P42574	1/20	0.54

▸	SENP7	Q9BQF6	1/20	0.54

▸	MAPT	P10636	5/20	0.52

▸	MEN1	O00255	1/20	0.52

▸	AR	P10275	1/20	0.52

▸	KMT2A	Q03164	1/20	0.52

▸	MAPK14	Q16539	2/20	0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Diphenylamine SCHEMBL28015233	0.97	HSD17B10 (0.67)	HSD17B10ALDH1A1TSHRTDP1L3MBTL1
Diphenylamine SCHEMBL1008716	0.97	HSD17B10 (0.67)	HSD17B10ALDH1A1TSHRTDP1L3MBTL1
Diphenylamine SCHEMBL1008717	0.97	HSD17B10 (0.67)	HSD17B10ALDH1A1TSHRTDP1L3MBTL1
Diphenylamine SCHEMBL7079615	0.92	HSD17B10 (0.60)	HSD17B10ALDH1A1TSHRTDP1L3MBTL1
Diphenylamine SCHEMBL28870226	0.92	HSD17B10 (0.60)	HSD17B10ALDH1A1TSHRTDP1L3MBTL1
Diphenylamine SCHEMBL1626446	0.88	MAPT (0.61)	HSD17B10ALDH1A1TSHRTDP1L3MBTL1
Diphenylamine SCHEMBL5665558	0.87	HSD17B10 (0.60)	HSD17B10ALDH1A1TSHRTDP1L3MBTL1
Sulfuric Acid SCHEMBL970713	0.84	MAPT (0.75)	HSD17B10ALDH1A1TSHRTDP1L3MBTL1
Diphenylamine SCHEMBL28944887	0.83	HSD17B10 (0.55)	HSD17B10ALDH1A1TSHRTDP1L3MBTL1
Diphenylamine SCHEMBL28417536	0.83	TSHR (0.73)	HSD17B10ALDH1A1TSHRTDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1667827-A4	PROCESS FOR THE TREATMENT OF WOOD	UNIV MELBOURNE (AU)	2007-11-28	—	—	EP	disclosed
US-20070056655-A1	Process for the treatment of wood	UNIVERSITY OF MELBOURNE (AU)	2007-03-15	—	—	US	disclosed
EP-1667827-A1	PROCESS FOR THE TREATMENT OF WOOD	THE UNIVERSITY OF MELBOURNE (AU)	2006-06-14	—	—	EP	disclosed
WO-2004113039-A1	PROCESS FOR THE TREATMENT OF WOOD	THE UNIVERSITY OF MELBOURNE (AU)	2004-12-29	—	—	WO	disclosed
US-5099006-A	ompounds for use in paints, for waterproofing, as adhesion promoters, mordants, sizing agents and intermediates	RHONE-POULENC INC. (US)	1992-03-24	—	—	US	disclosed
US-4800072-A	Anhydrous cerous nitrate-ammonium nitrate complex and a process for its preparation from ceric ammonium nitrate	RHONE POULENC, INC. (US)	1989-01-24	—	—	US	disclosed