Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Protirelin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRHR known ✓ | P34981 | 6/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Protirelin SCHEMBL10087855 | 1.00 | TRHR (1.00) | TRHR | |
| Protirelin SCHEMBL33419 | 1.00 | TRHR (1.00) | TRHR | |
| Protirelin SCHEMBL16091769 | 1.00 | TRHR (1.00) | TRHR | |
| Protirelin SCHEMBL4406163 | 0.97 | TRHR (0.93) | TRHR | |
| Protirelin SCHEMBL1007386 | 0.95 | TRHR (0.91) | TRHR | |
| SCHEMBL29539733 | 0.92 | TRHR (0.85) | TRHR | |
| Azetirelin SCHEMBL195158 | 0.92 | TRHR (0.85) | TRHR | |
| Protirelin SCHEMBL11309963 | 0.92 | TRHR (0.84) | TRHR | |
| SCHEMBL16072685 | 0.91 | TRHR (0.84) | TRHR | |
| SCHEMBL16088505 | 0.91 | TRHR (0.84) | TRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3655009-B1 | NANOPARTICLE COMPOSITIONS | YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD (IL) | 2023-10-11 | — | — | EP | disclosed |
| US-11660270-B2 | Nanoparticle compositions | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2023-05-30 | — | — | US | disclosed |
| US-20120015866-A1 | Prodrugs of Heteraromatic Compounds | ALKERMES, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| WO-2011084848-A2 | PRODRUGS OF HETERAROMATIC COMPOUNDS | ALKERMES, INC. (US) | 2011-07-14 | — | — | WO | disclosed |
| US-7713935-B2 | Compounds that modulate TRH actions | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2010-05-11 | — | — | US | disclosed |
| US-7462595-B2 | Methods for treating cancer-related fatigue | TRH THERAPEUTICS LLC | 2008-12-09 | — | — | US | disclosed |
| US-20070265202-A1 | Compounds That Modulate Trh Actions | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE O (IE) | 2007-11-15 | — | — | US | disclosed |
| US-20070265202-A1 | Compounds That Modulate Trh Actions | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE O (IE) | 2007-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015866-A1 | Prodrugs of Heteraromatic Compounds | CYP2D6, CYP2B6, CYP3A4 | TRHR 1939/4885 |
| US-11660270-B2 | Nanoparticle compositions | NAPEPLD, PHOSPHO1, LIPA | TRHR 4672/4885 |
| US-20070265202-A1 | Compounds That Modulate Trh Actions | TRHR, TRHDE, TSHR | TRHR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.