SCHEMBL10089968

SCHEMBL10089968

Cc1cc(Cl)cc(C(=O)NC(C)c2ccccc2)c1NC(=O)c1cc(Cn2nnc(C(F)(F)F)n2)nn1-c1ncccc1Cl

nearest known ligand 0.51

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 4/20 0.35
PTGDR Q13258 2/20 0.35
MAPT P10636 1/20 0.34
WDR5 P61964 2/20 0.33
GLS O94925 4/20 0.33
DGAT2 Q96PD7 2/20 0.33
PPARG P37231 3/20 0.33
CARM1 Q86X55 2/20 0.32
MAPK14 Q16539 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10089860 1.00 PTGER4 (0.35) PTGER4PTGDRMAPTWDR5GLS
SCHEMBL10089877 0.96 PTGER4 (0.35) PTGER4PTGDRWDR5DGAT2PPARG
SCHEMBL10090016 0.95 PTGER4 (0.35) PTGER4PTGDRWDR5DGAT2PPARG
SCHEMBL10089961 0.95 WDR5 (0.34) PTGER4PTGDRWDR5DGAT2PPARG
SCHEMBL10089927 0.95 WDR5 (0.37) PTGER4PTGDRWDR5DGAT2PPARG
SCHEMBL10089930 0.95 PTGER4 (0.40) PTGER4PTGDRWDR5PPARG
SCHEMBL10089993 0.95 PPARG (0.34) PTGER4PTGDRWDR5DGAT2PPARG
SCHEMBL10089998 0.94 WDR5 (0.34) PTGER4PTGDRWDR5DGAT2PPARG
SCHEMBL10089911 0.94 CNR1 (0.35) WDR5DGAT2PPARG
SCHEMBL10089999 0.94 PTGER4 (0.37) PTGER4PTGDRWDR5PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8791143-B2 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains DDT, ADCY1, ANTXR2 PTGER4 2569/4885PTGDR 763/4885MAPT 4663/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.