SCHEMBL10089998

SCHEMBL10089998

Cc1cccc(C(C)NC(=O)c2cc(Cl)cc(C)c2NC(=O)c2cc(Cn3nnc(C(F)(F)F)n3)nn2-c2ncccc2Cl)c1

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
WDR5 P61964 2/20 0.34
KCNB1 Q14721 2/20 0.33
KCNA5 P22460 1/20 0.33
KCNH2 Q12809 1/20 0.33
PPARG P37231 5/20 0.33
PTGER4 P35408 2/20 0.32
PTGDR Q13258 2/20 0.32
DHODH Q02127 2/20 0.31
KLKB1 P03952 1/20 0.31
DGAT2 Q96PD7 2/20 0.31
TRPM8 Q7Z2W7 1/20 0.30
KCNT1 Q5JUK3 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10089993 0.96 PPARG (0.34) WDR5PPARGPTGER4PTGDRDHODH
SCHEMBL10089911 0.94 CNR1 (0.35) WDR5PPARGDGAT2
SCHEMBL10089893 0.94 PPARG (0.37) WDR5PPARGPTGER4PTGDRDHODH
SCHEMBL10089968 0.94 PTGER4 (0.35) WDR5PPARGPTGER4PTGDRDGAT2
SCHEMBL10089860 0.94 PTGER4 (0.35) WDR5PPARGPTGER4PTGDRDGAT2
SCHEMBL10090016 0.94 PTGER4 (0.35) WDR5PPARGPTGER4PTGDRDHODH
SCHEMBL10089961 0.94 WDR5 (0.34) WDR5PPARGPTGER4PTGDRDHODH
SCHEMBL10089884 0.93 WDR5 (0.36) WDR5PPARGPTGER4PTGDRDHODH
SCHEMBL10089877 0.93 PTGER4 (0.35) WDR5PPARGPTGER4PTGDRDHODH
SCHEMBL10089927 0.92 WDR5 (0.37) WDR5PPARGPTGER4PTGDRDGAT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2582695-B1 ANTHRANILIC ACID DIAMIDE DERIVATIVES WITH CYCLICAL SIDE CHAINS BAYER IP GMBH (DE) 2015-09-30 EP disclosed
US-8791143-B2 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains DDT, ADCY1, ANTXR2 WDR5 2893/4885KCNB1 1400/4885KCNA5 846/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.