SCHEMBL10089993

SCHEMBL10089993

Cc1cc(Cl)cc(C(=O)NC(C)c2cccc(Cl)c2)c1NC(=O)c1cc(Cn2nnc(C(F)(F)F)n2)nn1-c1ncccc1Cl

nearest known ligand 0.49

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PPARG P37231 5/20 0.34
MAPK1 P28482 3/20 0.34
WDR5 P61964 2/20 0.34
PTGER4 P35408 2/20 0.33
PTGDR Q13258 2/20 0.33
PDPK1 O15530 1/20 0.33
RIPK1 Q13546 1/20 0.33
EIF2S1 P05198 1/20 0.32
EIF2AK3 Q9NZJ5 1/20 0.32
DHODH Q02127 2/20 0.32
DGAT2 Q96PD7 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10089998 0.96 WDR5 (0.34) PPARGWDR5PTGER4PTGDRDHODH
SCHEMBL10089961 0.95 WDR5 (0.34) PPARGWDR5PTGER4PTGDRDHODH
SCHEMBL10089893 0.95 PPARG (0.37) PPARGWDR5PTGER4PTGDRDHODH
SCHEMBL10089911 0.95 CNR1 (0.35) PPARGMAPK1WDR5RIPK1DGAT2
SCHEMBL10089968 0.95 PTGER4 (0.35) PPARGWDR5PTGER4PTGDRDGAT2
SCHEMBL10089860 0.95 PTGER4 (0.35) PPARGWDR5PTGER4PTGDRDGAT2
SCHEMBL10089884 0.94 WDR5 (0.36) PPARGMAPK1WDR5PTGER4PTGDR
SCHEMBL10089877 0.94 PTGER4 (0.35) PPARGWDR5PTGER4PTGDRDHODH
SCHEMBL10090016 0.93 PTGER4 (0.35) PPARGWDR5PTGER4PTGDRDHODH
SCHEMBL10089927 0.92 WDR5 (0.37) PPARGWDR5PTGER4PTGDRDGAT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8791143-B2 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains DDT, ADCY1, ANTXR2 PPARG 3227/4885MAPK1 2923/4885WDR5 2893/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.