SCHEMBL10089976

SCHEMBL10089976

Cc1cc(C#N)cc(C(=O)NC2CCCC2)c1NC(=O)c1cc(Cn2nnc(C(F)(F)F)n2)nn1-c1ncccc1Cl

nearest known ligand 0.43

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
OPRL1 P41146 6/20 0.37
CRHR1 P34998 3/20 0.35
RORC P51449 3/20 0.34
SLC2A1 P11166 1/20 0.34
SLC2A2 P11168 1/20 0.34
SLC2A3 P11169 1/20 0.34
SLC2A4 P14672 1/20 0.34
KCNH2 Q12809 4/20 0.33
MAPK13 O15264 1/20 0.33
MAPK12 P53778 1/20 0.33
MAPK11 Q15759 1/20 0.33
MAPK14 Q16539 1/20 0.33
CNR2 P34972 5/20 0.33
CNR1 P21554 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13085443 0.99 OPRL1 (0.36) OPRL1CRHR1RORCSLC2A1SLC2A2
SCHEMBL13084937 0.99 OPRL1 (0.35) OPRL1CRHR1RORCSLC2A1SLC2A2
SCHEMBL10075531 0.97 CRHR1 (0.37) OPRL1CRHR1RORCSLC2A1SLC2A2
SCHEMBL13084846 0.94 RORC (0.34) OPRL1CRHR1RORCSLC2A1SLC2A2
SCHEMBL10090014 0.94 MAPK14 (0.34) CRHR1RORCSLC2A1SLC2A2SLC2A3
SCHEMBL10089851 0.93 RORC (0.38) OPRL1CRHR1RORCSLC2A1SLC2A2
SCHEMBL10089865 0.93 SLC2A1 (0.34) OPRL1CRHR1RORCSLC2A1SLC2A2
SCHEMBL13085326 0.93 CRHR1 (0.34) CRHR1RORCSLC2A1SLC2A2SLC2A3
SCHEMBL686718 0.93 CRHR1 (0.35) CRHR1RORCSLC2A1SLC2A2SLC2A3
SCHEMBL317729 0.92 ELANE (0.33) OPRL1CRHR1RORCSLC2A1SLC2A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8791143-B2 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-8324390-B2 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2012-12-04 US disclosed
US-8324390-B2 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2012-12-04 US disclosed
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2010-10-07 US disclosed
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2010-10-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains DDT, ADCY1, ANTXR2 OPRL1 3464/4885CRHR1 3984/4885RORC 3664/4885
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides ANTXR2, PNISR, H1-5 OPRL1 3317/4885CRHR1 4225/4885RORC 3454/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.