Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COPS5 | Q92905 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DHPS | P49366 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011805 | 0.89 | COPS5 (0.36) | COPS5EGLN1L3MBTL1MAPTDHPS | |
| SCHEMBL1009458 | 0.82 | ACE (0.42) | L3MBTL1MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL1923117 | 0.82 | ACE (0.42) | L3MBTL1MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL1010222 | 0.81 | TBXA2R (0.38) | COPS5EGLN1LMNAALDH1A1TDP1 | |
| SCHEMBL1924122 | 0.81 | TBXA2R (0.38) | COPS5EGLN1LMNAALDH1A1TDP1 | |
| SCHEMBL1010089 | 0.77 | GAA (0.39) | LMNAALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL3443252 | 0.75 | NPSR1 (0.40) | COPS5EGLN1L3MBTL1MAPTDHPS | |
| SCHEMBL1010960 | 0.75 | ACE (0.41) | EGLN1MAPTLMNAKMT2ACYP2C9 | |
| SCHEMBL1012425 | 0.75 | TBXA2R (0.41) | EGLN1L3MBTL1MAPTLMNAALDH1A1 | |
| SCHEMBL1010138 | 0.74 | CHRM3 (0.40) | COPS5EGLN1L3MBTL1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960393-B2 | Pyrimidine derivatives useful for the treatment of diseases mediated by CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| EP-1633726-B1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS INC (US) | 2011-01-05 | — | — | EP | disclosed |