Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.32 |
| ▸ | PRNP | P04156 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011805 | 0.87 | COPS5 (0.36) | TBXA2RPTGDRPTGDR2MAPTSMN1; SMN2 | |
| SCHEMBL1009538 | 0.82 | ALDH1A1 (0.39) | TBXA2RPTGDRPTGDR2MAPTSMN1; SMN2 | |
| SCHEMBL1009772 | 0.82 | NR1H4 (0.48) | TBXA2RPTGDRPTGDR2MEN1KMT2A | |
| SCHEMBL3443023 | 0.79 | PTGDR2 (0.57) | TBXA2RPTGDRPTGDR2MAPTSMN1; SMN2 | |
| SCHEMBL1924122 | 0.78 | TBXA2R (0.38) | TBXA2RPTGDRPTGDR2LMNAALDH1A1 | |
| SCHEMBL1010222 | 0.78 | TBXA2R (0.38) | TBXA2RPTGDRPTGDR2LMNAALDH1A1 | |
| SCHEMBL1009043 | 0.75 | COPS5 (0.40) | MAPTLMNAALDH1A1EGLN1L3MBTL1 | |
| SCHEMBL12569007 | 0.75 | TBXA2R (0.45) | TBXA2RPTGDRPTGDR2MAPTSMN1; SMN2 | |
| SCHEMBL1010635 | 0.74 | POLB (0.40) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1922623 | 0.74 | POLB (0.40) | SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960393-B2 | Pyrimidine derivatives useful for the treatment of diseases mediated by CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| EP-1633726-B1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS INC (US) | 2011-01-05 | — | — | EP | disclosed |