Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.34 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.34 |
| ▸ | ALB | P02768 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | RARB | P10826 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1924122 | 1.00 | TBXA2R (0.38) | TBXA2RPTGDRPTGDR2COPS5HTR2C | |
| SCHEMBL1011805 | 0.92 | COPS5 (0.36) | TBXA2RPTGDRPTGDR2COPS5HTR2C | |
| SCHEMBL1009771 | 0.84 | CPB2 (0.36) | TBXA2RPTGDRPTGDR2COPS5PTGS1 | |
| SCHEMBL1010635 | 0.83 | POLB (0.40) | ENPP1 | |
| SCHEMBL1922623 | 0.83 | POLB (0.40) | ENPP1 | |
| SCHEMBL1009043 | 0.81 | COPS5 (0.40) | COPS5PTGS1PTGS2AKR1C3LMNA | |
| SCHEMBL2787854 | 0.78 | TBXA2R (0.57) | TBXA2RPTGDRPTGDR2COPS5HTR2C | |
| SCHEMBL3443468 | 0.78 | TBXA2R (0.57) | TBXA2RPTGDRPTGDR2COPS5HTR2C | |
| SCHEMBL1012425 | 0.78 | TBXA2R (0.41) | TBXA2RPTGDRPTGDR2HTR2CPTGS1 | |
| SCHEMBL1010909 | 0.76 | CYP2C19 (0.38) | CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960393-B2 | Pyrimidine derivatives useful for the treatment of diseases mediated by CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| EP-1633726-B1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS INC (US) | 2011-01-05 | — | — | EP | disclosed |