Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.43 |
| ▸ | STK39 | Q9UEW8 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL963842 | 1.00 | L3MBTL1 (0.46) | L3MBTL1LMNANPSR1HTTALDH1A1 | |
| SCHEMBL963843 | 1.00 | L3MBTL1 (0.46) | L3MBTL1LMNANPSR1HTTALDH1A1 | |
| SCHEMBL15381595 | 0.88 | PTGER4 (0.41) | L3MBTL1LMNANPSR1PTGER4SMN1; SMN2 | |
| SCHEMBL9949099 | 0.84 | L3MBTL1 (0.51) | L3MBTL1LMNANPSR1HTTALDH1A1 | |
| SCHEMBL10093205 | 0.84 | L3MBTL1 (0.51) | L3MBTL1LMNANPSR1HTTALDH1A1 | |
| SCHEMBL9949101 | 0.84 | L3MBTL1 (0.51) | L3MBTL1LMNANPSR1HTTALDH1A1 | |
| SCHEMBL9948495 | 0.78 | CYP1A2 (0.54) | L3MBTL1LMNANPSR1HTTALDH1A1 | |
| SCHEMBL22891351 | 0.77 | CYP1A2 (0.57) | L3MBTL1LMNANPSR1HTTALDH1A1 | |
| SCHEMBL11354413 | 0.76 | CYP1A2 (0.56) | L3MBTL1LMNANPSR1HTTALDH1A1 | |
| SCHEMBL12505440 | 0.75 | CTNNB1 (0.65) | L3MBTL1LMNANPSR1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165545-A1 | PROCESSES FOR THE PREPARATION OF 5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE | MEDICHEM, S.A. (ES) | 2012-06-28 | — | — | US | disclosed |
| US-7875729-B2 | Trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino [4,5-c]pyrrole; good isomeric purity; cyclization | SYNTHON BV (NL) | 2011-01-25 | — | — | US | disclosed |
| US-20080214832-A1 | Process for making asenapine | SYNTHON BV (NL) | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214832-A1 | Process for making asenapine | CYP3A5, CYP3A4, CYP2C9 | L3MBTL1 4338/4885LMNA 919/4885NPSR1 1234/4885 |
| US-20120165545-A1 | PROCESSES FOR THE PREPARATION OF 5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE | DHPS, CYP3A5, ALKBH5 | L3MBTL1 4473/4885LMNA 4222/4885NPSR1 2293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.