Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | STK39 | Q9UEW8 | 3/20 | 0.49 |
| ▸ | PARG | Q86W56 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861651 | 0.90 | KMT2A (0.55) | CYP1A2CYP2C9CYP2C19KMT2ASTK39 | |
| SCHEMBL22891351 | 0.87 | CYP1A2 (0.57) | CYP1A2CYP3A4CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL11354413 | 0.85 | CYP1A2 (0.56) | CYP1A2CYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL28949682 | 0.84 | CYP1A2 (0.54) | CYP1A2CYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL12505440 | 0.84 | CTNNB1 (0.65) | CYP1A2CYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL5554679 | 0.81 | BRD4 (0.52) | CYP1A2CYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL19524223 | 0.81 | SCN8A (0.56) | KMT2AL3MBTL1LMNASMN1; SMN2CTNNB1 | |
| SCHEMBL13752348 | 0.80 | KMT2A (0.46) | CYP3A4KMT2ALMNAMRGPRX4SMN1; SMN2 | |
| SCHEMBL6447800 | 0.80 | TTR (0.56) | KMT2AL3MBTL1LMNASTK39MRGPRX4 | |
| SCHEMBL2303571 | 0.80 | MAPT (0.60) | CYP1A2CYP2C9CYP2C19KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159549-A1 | METHOD FOR PREPARATION OF ASENAPINE | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2023-05-25 | — | — | US | disclosed |
| US-20230159549-A1 | METHOD FOR PREPARATION OF ASENAPINE | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2023-05-25 | — | — | US | disclosed |
| EP-4015519-A1 | METHOD OF PREPARING ASENAPINE | Zhejiang Ausun Pharmaceutical Co., Ltd. (CN) | 2022-06-22 | — | — | EP | disclosed |
| WO-2021027813-A1 | METHOD OF PREPARING ASENAPINE | 浙江奥翔药业股份有限公司 | 2021-02-18 | — | — | WO | disclosed |
| EP-2468751-B1 | Processes for the preparation of 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole | MEDICHEM SA (ES) | 2016-03-16 | — | — | EP | disclosed |
| EP-2468751-B1 | Processes for the preparation of 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole | MEDICHEM SA (ES) | 2016-03-16 | — | — | EP | disclosed |
| US-8580972-B2 | Processes for the preparation of 5-chloro-2-methyl-2,3,3A,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole | MEDICHEM, S.A. (ES) | 2013-11-12 | — | — | US | disclosed |
| US-8580972-B2 | Processes for the preparation of 5-chloro-2-methyl-2,3,3A,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole | MEDICHEM, S.A. (ES) | 2013-11-12 | — | — | US | disclosed |
| US-8580972-B2 | Processes for the preparation of 5-chloro-2-methyl-2,3,3A,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole | MEDICHEM, S.A. (ES) | 2013-11-12 | — | — | US | disclosed |
| US-20120165545-A1 | PROCESSES FOR THE PREPARATION OF 5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE | MEDICHEM, S.A. (ES) | 2012-06-28 | — | — | US | disclosed |
| US-20120165545-A1 | PROCESSES FOR THE PREPARATION OF 5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE | MEDICHEM, S.A. (ES) | 2012-06-28 | — | — | US | disclosed |
| US-20120165545-A1 | PROCESSES FOR THE PREPARATION OF 5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE | MEDICHEM, S.A. (ES) | 2012-06-28 | — | — | US | disclosed |
| EP-2468751-A2 | Processes for the preparation of 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole | Medichem, S.A. (ES) | 2012-06-27 | — | — | EP | disclosed |
| EP-2468751-A2 | Processes for the preparation of 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole | Medichem, S.A. (ES) | 2012-06-27 | — | — | EP | disclosed |
| US-20090209608-A1 | DEUTERIUM-ENRICHED ASENAPINE | PROTIA, LLC (US) | 2009-08-20 | — | — | US | disclosed |
| US-20090209608-A1 | DEUTERIUM-ENRICHED ASENAPINE | PROTIA, LLC (US) | 2009-08-20 | — | — | US | disclosed |
| US-4180559-A | Coated 1-(2-chlorodibenzo[b,f]oxepin-10-yl)-4-methylpiperazine compositions | RICHARDSON-MERRELL INC. (US) | 1979-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159549-A1 | METHOD FOR PREPARATION OF ASENAPINE | CYP3A5, QDPR, SPR | CYP1A2 139/4885CYP3A4 73/4885CYP2C9 106/4885 |
| US-20090209608-A1 | DEUTERIUM-ENRICHED ASENAPINE | NSD2, DRD2, SNRPD2 | CYP1A2 646/4885CYP3A4 460/4885CYP2C9 498/4885 |
| US-20120165545-A1 | PROCESSES FOR THE PREPARATION OF 5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE | DHPS, CYP3A5, ALKBH5 | CYP1A2 24/4885CYP3A4 34/4885CYP2C9 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.