Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.42 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.42 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10094498 | 0.82 | NCOA1 (0.46) | TRPV1RIPK1MAPK1KDM4EALDH1A1 | |
| SCHEMBL27914704 | 0.78 | MKNK1 (0.71) | MKNK1MKNK2RIPK1CAMKK2MAPKAPK2 | |
| SCHEMBL10094510 | 0.77 | RIPK1 (0.53) | TRPV1RIPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10094460 | 0.77 | SYK (0.45) | TRPV1KDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL14555428 | 0.77 | MKNK1 (0.68) | MKNK1MKNK2RIPK1CAMKK2MAPKAPK2 | |
| SCHEMBL29857184 | 0.77 | GABRA1 (0.43) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10094579 | 0.77 | GABRA1 (0.43) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10094462 | 0.77 | TRPV1 (0.52) | TRPV1KDM4ENPC1ALDH1A1CYP1A2 | |
| SCHEMBL10094476 | 0.76 | MAPK14 (0.43) | — | |
| SCHEMBL10094473 | 0.76 | TRPV1 (0.43) | TRPV1KDM4ENPC1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148535-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-04-03 | — | — | US | disclosed |
| US-20090233897-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233897-A1 | Potassium Channel Inhibitors | KCNJ2, KCNQ2, KCNH2 | MKNK1 295/4885MKNK2 330/4885TRPV1 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.