Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASAH1 | Q13510 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | CERT1 | Q9Y5P4 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11831229 | 0.85 | ASAH1 (0.50) | ASAH1HDAC1HDAC8RIPK1TBXAS1 | |
| SCHEMBL6907995 | 0.85 | TBXAS1 (0.58) | ASAH1HDAC1HDAC8RIPK1TBXAS1 | |
| SCHEMBL9308449 | 0.85 | TBXAS1 (0.58) | ASAH1HDAC1HDAC8RIPK1TBXAS1 | |
| SCHEMBL8942907 | 0.85 | ASAH1 (0.50) | ASAH1HDAC1HDAC8RIPK1TBXAS1 | |
| SCHEMBL11836011 | 0.85 | ASAH1 (0.50) | ASAH1HDAC1HDAC8RIPK1TBXAS1 | |
| SCHEMBL6907990 | 0.85 | TBXAS1 (0.58) | ASAH1HDAC1HDAC8RIPK1TBXAS1 | |
| SCHEMBL27820361 | 0.83 | TBXAS1 (0.55) | ASAH1HDAC1HDAC8RIPK1TBXAS1 | |
| SCHEMBL27585172 | 0.83 | TBXAS1 (0.55) | ASAH1HDAC1HDAC8RIPK1TBXAS1 | |
| SCHEMBL11828179 | 0.80 | RIPK1 (0.61) | RIPK1LMNABCAT2L3MBTL1KDM4E | |
| SCHEMBL6392113 | 0.77 | HDAC1 (0.67) | HDAC1HDAC8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124778-B2 | Tricyclic inhibitors of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-02-28 | — | — | US | disclosed |
| US-20100216750-A1 | TRICYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216750-A1 | TRICYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | FADS1, FAAH, SCD | ASAH1 55/4885HDAC1 129/4885HDAC8 214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.