Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 5/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.41 |
| ▸ | PGR | P06401 | 3/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.41 |
| ▸ | AR | P10275 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10095770 | 0.93 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1USP2CYP1A2CYP3A4 | |
| SCHEMBL10095687 | 0.92 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1GRIK2USP2CYP1A2 | |
| SCHEMBL10095478 | 0.92 | CYP11B2 (0.47) | HSP90AA1HSP90AB1GRIK2TSHRLMNA | |
| SCHEMBL10095711 | 0.91 | GRIK2 (0.41) | HSP90AA1HSP90AB1GRIK2TSHRLMNA | |
| SCHEMBL10095713 | 0.90 | GRIK2 (0.40) | HSP90AA1HSP90AB1GRIK2USP2CYP1A2 | |
| SCHEMBL10097264 | 0.90 | GRIK2 (0.40) | HSP90AA1HSP90AB1GRIK2CYP1A2CYP3A4 | |
| SCHEMBL979541 | 0.89 | GRIK2 (0.46) | HSP90AA1HSP90AB1GRIK2LMNAMEN1 | |
| SCHEMBL10095746 | 0.89 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1GRIK2TSHRLMNA | |
| SCHEMBL10095714 | 0.88 | MAPK1 (0.39) | HSP90AA1HSP90AB1GRIK2TSHRLMNA | |
| SCHEMBL10095748 | 0.87 | KDM4E (0.41) | HSP90AA1HSP90AB1GRIK2TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120027721-A1 | HCV Inhibitor and Therapeutic Agent Combinations | PTC THERAPEUTICS, INC. (US) | 2012-02-02 | — | — | US | disclosed |
| US-20120009142-A1 | METHODS FOR TREATING HEPATITIS C | PTC THERAPEUTICS, INC. (US) | 2012-01-12 | — | — | US | disclosed |
| US-8013006-B2 | Methods for treating hepatitis C | PTC THERAPEUTICS, INC. (US) | 2011-09-06 | — | — | US | disclosed |
| US-7868037-B2 | Methods for treating hepatitis C | PTC THERAPEUTICS, INC. (US) | 2011-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120009142-A1 | METHODS FOR TREATING HEPATITIS C | OAT, HAVCR2, HCCS | HSP90AA1 369/4885HSP90AB1 258/4885GRIK2 4399/4885 |
| US-20120027721-A1 | HCV Inhibitor and Therapeutic Agent Combinations | HAVCR2, SERPINB1, ENPEP | HSP90AA1 148/4885HSP90AB1 66/4885GRIK2 4491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.