Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.43 |
| ▸ | GAA | P10253 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 5/20 | 0.33 |
| ▸ | NOS3 | P29474 | 3/20 | 0.33 |
| ▸ | NOS2 | P35228 | 3/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10099718 | 0.73 | TERT (0.48) | MAPTHTTALDH1A1NOS1NOS3 | |
| SCHEMBL11769838 | 0.68 | ALDH1A1 (0.47) | MAPTGAAKDM4EHTTKMT2A | |
| SCHEMBL1520855 | 0.66 | TSHR (0.38) | MAPTGAAKDM4EHTTKMT2A | |
| SCHEMBL3233672 | 0.58 | TERT (0.39) | ALDH1A1RIPK1 | |
| SCHEMBL12951316 | 0.57 | CHRNA7 (0.42) | ALDH1A1NOS1NOS3NOS2 | |
| SCHEMBL9383590 | 0.55 | RIPK1 (0.51) | KMT2AALDH1A1POLBRIPK1 | |
| SCHEMBL5903097 | 0.55 | CA12 (0.41) | MAPTGAAKDM4EKMT2AALDH1A1 | |
| SCHEMBL28936925 | 0.55 | MEN1 (0.38) | MAPTGAAKMT2AALDH1A1HPGD | |
| SCHEMBL28953414 | 0.55 | RIPK1 (0.33) | MAPTKDM4EKMT2AALDH1A1POLB | |
| SCHEMBL9380053 | 0.55 | RIPK1 (0.53) | ALDH1A1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | disclosed |