Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 9/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10103461 | 0.92 | HTT (0.36) | HIF1AHTR3EHTR3BCHRNA7HTR3A | |
| SCHEMBL10103199 | 0.91 | HTR3E (0.42) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL10103445 | 0.89 | HSD11B1 (0.42) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL525274 | 0.86 | HSD11B1 (0.52) | HSD11B1IDH1 | |
| SCHEMBL10086305 | 0.86 | HSD11B1 (0.52) | HSD11B1IDH1 | |
| SCHEMBL10103350 | 0.84 | HSD11B1 (0.43) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL10103477 | 0.83 | NPC1 (0.52) | HSD11B1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10103112 | 0.80 | HSD11B1 (0.42) | HSD11B1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10103465 | 0.79 | TRPC3 (0.35) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL10103346 | 0.78 | HSD11B1 (0.34) | HTR3EHTR3BCHRNA7HTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012015715-A1 | SUBSTITUTED THIAZOL-2-YLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS 11-BETA HSD1 MODULATORS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2012-02-02 | — | — | WO | disclosed |