Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 10/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10086121 | 0.86 | HSD11B1 (0.61) | NPC1HSD11B1 | |
| SCHEMBL525571 | 0.86 | HSD11B1 (0.61) | NPC1HSD11B1 | |
| SCHEMBL10103468 | 0.83 | HIF1A (0.40) | NPC1HSD11B1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL10103461 | 0.76 | HTT (0.36) | NPC1HSD11B1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL10103199 | 0.75 | HTR3E (0.42) | HSD11B1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL10103445 | 0.73 | HSD11B1 (0.42) | NPC1HSD11B1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL525062 | 0.70 | NPC1 (1.00) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL14135317 | 0.69 | FAAH (0.45) | NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL10086305 | 0.69 | HSD11B1 (0.52) | HSD11B1 | |
| SCHEMBL525274 | 0.69 | HSD11B1 (0.52) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012015715-A1 | SUBSTITUTED THIAZOL-2-YLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS 11-BETA HSD1 MODULATORS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2012-02-02 | — | — | WO | disclosed |