Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | MPL | P40238 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HTR5A | P47898 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15487819 | 0.82 | GRM5 (0.41) | ALDH1A1GRM5HTR2CKDM4EMEN1 | |
| SCHEMBL1009344 | 0.77 | CYP19A1 (0.41) | ALDH1A1NOTUMGRM5GRM1HTR2C | |
| SCHEMBL1011370 | 0.77 | ALDH1A1 (0.47) | ALDH1A1NOTUMHTR2CKDM4EMEN1 | |
| SCHEMBL1010644 | 0.76 | METAP1 (0.37) | ALDH1A1L3MBTL1HSD11B1NOTUMMETAP1 | |
| SCHEMBL30167242 | 0.74 | CYP19A1 (0.41) | ALDH1A1HSD11B1NOTUMGRM5GRM1 | |
| SCHEMBL29607356 | 0.74 | PARP10 (0.42) | ALDH1A1GRM5GRM1HTR2CKDM4E | |
| SCHEMBL28164453 | 0.74 | PARP1 (0.42) | ALDH1A1L3MBTL1HTR2CKDM4EMEN1 | |
| SCHEMBL1010129 | 0.74 | CYP19A1 (0.41) | ALDH1A1HSD11B1NOTUMGRM5GRM1 | |
| SCHEMBL1011067 | 0.74 | PARP10 (0.42) | ALDH1A1GRM5GRM1HTR2CKDM4E | |
| SCHEMBL28163806 | 0.74 | PARP1 (0.42) | ALDH1A1HTR2CKDM4EMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2888259-B1 | DIAZEPINONE DERIVATIVES USEFUL FOR THE TREATMENT OF FRAGILE X SYNDROME, PARKINSONS OR REFLUX DISEASE | NOVARTIS AG (CH) | 2018-03-07 | — | — | EP | disclosed |
| US-20170305903-A1 | DIAZEPINONE DERIVATIVES | NOVARTIS AG (CH) | 2017-10-26 | — | — | US | disclosed |
| US-9650377-B2 | Diazepinone derivatives | NOVARTIS AG (CH) | 2017-05-16 | — | — | US | disclosed |
| US-20160159795-A1 | DIAZEPINONE DERIVATIVES | NOVARTIS AG (CH) | 2016-06-09 | — | — | US | disclosed |
| US-9284331-B2 | Diazepinone derivatives | NOVARTIS AG (CH) | 2016-03-15 | — | — | US | disclosed |
| EP-2888259-A1 | DIAZEPINONE DERIVATIVES USEFUL FOR THE TREATMENT OF FRAGILE X SYNDROME, PARKINSONS OR REFLUX DISEASE | Novartis AG (CH) | 2015-07-01 | — | — | EP | disclosed |
| US-20140357625-A1 | DIAZEPINONE DERIVATIVES | NOVARTIS AG (CH) | 2014-12-04 | — | — | US | disclosed |
| US-8853203-B2 | Diazepinone derivatives | NOVARTIS AG (CH) | 2014-10-07 | — | — | US | disclosed |
| WO-2014030128-A1 | DIAZEPINONE DERIVATIVES USEFUL FOR THE TREATMENT OF FRAGILE X SYNDROME, PARKINSONS OR REFLUX DISEASE | NOVARTIS AG (CH) | 2014-02-27 | — | — | WO | disclosed |
| US-20140057902-A1 | Diazepinone derivatives | NOVARTIS AG (CH) | 2014-02-27 | — | — | US | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |
| CN-101501036-A | Substituted pyrazolopyrimidines, a process for their preparation and their use as medicine | MERZ PHARMA GMBH & CO KGAA (DE) | 2009-08-05 | — | — | CN | disclosed |
| EP-2054416-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | Merz Pharma GmbH & Co. KGaA (DE) | 2009-05-06 | — | — | EP | disclosed |
| US-20080039458-A1 | Substituted pyrazolopyrimidines, a process for their preparation and their use as medicine | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-02-14 | — | — | US | disclosed |
| US-20080039458-A1 | Substituted pyrazolopyrimidines, a process for their preparation and their use as medicine | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-02-14 | — | — | US | disclosed |
| US-20080039458-A1 | Substituted pyrazolopyrimidines, a process for their preparation and their use as medicine | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-02-14 | — | — | US | disclosed |
| WO-2008015269-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-02-07 | — | — | WO | disclosed |
| WO-2008015269-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140057902-A1 | Diazepinone derivatives | ADRB1, ADRB2, BRD4 | ALDH1A1 482/4885L3MBTL1 4870/4885HSD11B1 135/4885 |
| US-20160159795-A1 | DIAZEPINONE DERIVATIVES | ADRB1, ADRB2, BRD4 | ALDH1A1 482/4885L3MBTL1 4870/4885HSD11B1 135/4885 |
| US-20080039458-A1 | Substituted pyrazolopyrimidines, a process for their preparation and their use as medicine | GRM5, GRM1, GRM3 | ALDH1A1 3094/4885L3MBTL1 2526/4885HSD11B1 2348/4885 |
| US-20170305903-A1 | DIAZEPINONE DERIVATIVES | ADRB1, ADRB2, BRD4 | ALDH1A1 482/4885L3MBTL1 4870/4885HSD11B1 135/4885 |
| US-20140357625-A1 | DIAZEPINONE DERIVATIVES | ADRB1, ADRB2, BRD4 | ALDH1A1 482/4885L3MBTL1 4870/4885HSD11B1 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.