Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 7/20 | 0.62 |
| ▸ | OSBP | P22059 | 5/20 | 0.62 |
| ▸ | OSBP2 | Q969R2 | 3/20 | 0.62 |
| ▸ | USP2 | O75604 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.62 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.62 |
| ▸ | RORA | P35398 | 3/20 | 0.52 |
| ▸ | NPC1L1 | Q9UHC9 | 3/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.52 |
| ▸ | GPR183 | P32249 | 1/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CRYAB | P02511 | 1/20 | 0.50 |
| ▸ | HMGCR | P04035 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGAV | P06756 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31305863 | 1.00 | RORC (0.62) | RORCOSBPOSBP2USP2LMNA | |
| SCHEMBL14864844 | 0.91 | RORC (0.66) | RORCOSBPOSBP2USP2LMNA | |
| SCHEMBL22150297 | 0.87 | RORC (0.61) | RORCOSBPOSBP2USP2LMNA | |
| SCHEMBL60576 | 0.86 | RORC (0.46) | RORCOSBPOSBP2USP2LMNA | |
| SCHEMBL3308174 | 0.84 | CYP17A1 (0.57) | LMNAGRIN1GRIN2AMEN1KMT2A | |
| SCHEMBL3308172 | 0.84 | CYP17A1 (0.57) | LMNAGRIN1GRIN2AMEN1KMT2A | |
| SCHEMBL18167509 | 0.81 | RORC (0.58) | RORCOSBPOSBP2USP2LMNA | |
| SCHEMBL22032747 | 0.81 | RORC (0.58) | RORCOSBPOSBP2USP2LMNA | |
| SCHEMBL18167508 | 0.81 | RORC (0.58) | RORCOSBPOSBP2USP2LMNA | |
| SCHEMBL9885952 | 0.80 | POLA1 (0.51) | CYP46A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040459-A1 | REDUCED SIZE SELF-DELIVERING RNAI COMPOUNDS | RXI PHARMACEUTICALS CORPORATION (US) | 2012-02-16 | — | — | US | disclosed |