Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | OSBP | P22059 | 1/20 | 0.46 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.46 |
| ▸ | EBP | Q15125 | 3/20 | 0.44 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.43 |
| ▸ | POLA1 | P09884 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.42 |
| ▸ | CDC25A | P30304 | 1/20 | 0.42 |
| ▸ | RORA | P35398 | 2/20 | 0.39 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
| ▸ | HMGCR | P04035 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10105385 | 0.86 | RORC (0.62) | RORCUSP2CYP46A1LMNAABCB1 | |
| SCHEMBL31305863 | 0.86 | RORC (0.62) | RORCUSP2CYP46A1LMNAABCB1 | |
| SCHEMBL9885952 | 0.77 | POLA1 (0.51) | CYP46A1POLA1 | |
| SCHEMBL14864844 | 0.76 | RORC (0.66) | RORCUSP2CYP46A1LMNAABCB1 | |
| SCHEMBL24264118 | 0.76 | USP2 (0.74) | RORCUSP2CYP46A1LMNAABCB1 | |
| SCHEMBL2631976 | 0.76 | USP2 (0.74) | RORCUSP2CYP46A1LMNAABCB1 | |
| SCHEMBL14558147 | 0.76 | USP2 (0.74) | RORCUSP2CYP46A1LMNAABCB1 | |
| SCHEMBL24927685 | 0.76 | USP2 (0.74) | RORCUSP2CYP46A1LMNAABCB1 | |
| SCHEMBL11977916 | 0.76 | USP2 (0.74) | RORCUSP2CYP46A1LMNAABCB1 | |
| SCHEMBL14052247 | 0.76 | USP2 (0.74) | RORCUSP2CYP46A1LMNAABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107106635-B | Pneumolysin mutants and methods of use thereof | 俄克拉何马大学董事会 | 2021-10-08 | — | — | CN | disclosed |
| US-10562941-B2 | Pneumolysin mutants and methods of use thereof | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2020-02-18 | — | — | US | disclosed |
| US-10364275-B2 | Methods for treating inflammatory responses or diseases caused by inflammation using ApoA-I binding protein (APOA1BP) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-07-30 | — | — | US | disclosed |
| US-20180312552-A1 | Pneumolysin Mutants and Methods of Use Thereof | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA | 2018-11-01 | — | — | US | disclosed |
| EP-3220937-A1 | PNEUMOLYSIN MUTANTS AND METHODS OF USE THEREOF | The Board of Regents of the University of Oklahoma (US) | 2017-09-27 | — | — | EP | disclosed |
| CN-107106635-A | Pneumolysin mutant and its application method | 俄克拉何马大学董事会 | 2017-08-29 | — | — | CN | disclosed |
| WO-2016081839-A1 | PNEUMOLYSIN MUTANTS AND METHODS OF USE THEREOF | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2016-05-26 | — | — | WO | disclosed |
| US-20160115211-A1 | COMPOSITIONS AND METHODS FOR REGULATING ANGIOGENESIS AND CHOLESTEROL AND TREATING DYSLIPIDEMIA, ATHEROSCLEROSIS, CANCER AND INFLAMMATORY CONDITIONS | UNIV CALIFORNIA (US) | 2016-04-28 | — | — | US | disclosed |
| US-9228001-B2 | Mutants of cholesterol-dependent cytolysins and uses thereof | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2016-01-05 | — | — | US | disclosed |
| WO-2014193822-A1 | COMPOSITIONS AND METHODS FOR REGULATING ANGIOGENESIS AND CHOLESTEROL AND TREATING DYSLIPIDEMIA, ATHEROSCLEROSIS, CANCER AND INFLAMMATORY CONDITIONS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-12-04 | — | — | WO | disclosed |
| US-8128939-B2 | Mutants of cholesterol-dependent cytolysins and uses thereof | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2012-03-06 | — | — | US | disclosed |
| US-20090285846-A1 | MUTANTS OF CHOLESTEROL-DEPENDENT CYTOLYSINS AND USES THEREOF | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA | 2009-11-19 | — | — | US | disclosed |