Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | AOC2 | O75106 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4377848 | 0.98 | MAOB (0.55) | MAOBDRD2DRD4DRD3MEN1 | |
| SCHEMBL15923247 | 0.91 | MEN1 (0.54) | MAOBMEN1LMNAHTTKMT2A | |
| SCHEMBL7972309 | 0.91 | MEN1 (0.54) | MAOBMEN1LMNAHTTKMT2A | |
| SCHEMBL322907 | 0.88 | TAAR1 (0.60) | MAOBDRD2DRD4DRD3CYP1A2 | |
| SCHEMBL991452 | 0.88 | TAAR1 (0.56) | TAAR1 | |
| SCHEMBL27972500 | 0.88 | MAOB (0.46) | MAOBDRD2DRD4DRD3MEN1 | |
| Hydrochloric Acid SCHEMBL321866 | 0.86 | TAAR1 (0.58) | MAOBMEN1LMNAKMT2ACYP1A2 | |
| SCHEMBL10338308 | 0.85 | MEN1 (0.60) | DRD2DRD4DRD3MEN1LMNA | |
| Hydrochloric Acid SCHEMBL6258205 | 0.85 | TAAR1 (0.54) | TAAR1 | |
| SCHEMBL9114592 | 0.83 | CYP1A2 (0.63) | MAOBDRD2DRD4DRD3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230127965-A1 | METHODS FOR TREATING, AMELIORATING, OR PREVENTING VIRAL INFECTIONS | UNIV JEFFERSON (US) | 2023-04-27 | — | — | US | disclosed |
| US-20200087730-A1 | METHODS OF IDENTIFYING AND TREATING TUMORS WITH SIGMA1 INHIBITORS | UNIV DREXEL (US) | 2020-03-19 | — | — | US | disclosed |
| US-10314795-B2 | Sigma receptor ligands and methods of modulating cellular protein homeostasis using same | DREXEL UNIVERSITY (US) | 2019-06-11 | — | — | US | disclosed |
| US-10314795-B2 | Sigma receptor ligands and methods of modulating cellular protein homeostasis using same | DREXEL UNIVERSITY (US) | 2019-06-11 | — | — | US | disclosed |
| US-20180235910-A1 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | Philadelphia Health And Education Corporation, d/b/a Drexel University College of Medicine | 2018-08-23 | — | — | US | disclosed |
| US-9889102-B2 | Sigma receptor ligands and methods of modulating cellular protein homeostasis using same | DREXEL UNIVERSITY (US) | 2018-02-13 | — | — | US | disclosed |
| US-9889102-B2 | Sigma receptor ligands and methods of modulating cellular protein homeostasis using same | DREXEL UNIVERSITY (US) | 2018-02-13 | — | — | US | disclosed |
| WO-2017106312-A1 | METHODS OF MODULATING LEVELS OF IL-6 AND PD-L1 | DREXEL UNIVERSITY (US) | 2017-06-22 | — | — | WO | disclosed |
| CN-104822653-B | N-prop-2-ynylcarboxamide derivatives and their use as TRPA1 antagonists | 奥赖恩公司 | 2017-03-08 | — | — | CN | disclosed |
| US-20160361279-A1 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | Philadelphia Health And Education Corporation, d/b/a Drexel University College of Medicine | 2016-12-15 | — | — | US | disclosed |
| CN-1845905-A | PPAR-activating compound and pharmaceutical composition comprising the compound | KOWA CO (JP) | 2006-10-11 | — | — | CN | disclosed |
| US-7109226-B2 | PPAR-activating compound and pharmaceutical composition comprising the compound | KOWA CO., LTD. (JP) | 2006-09-19 | — | — | US | disclosed |
| US-20060189667-A1 | PPAR-activating compound and pharmaceutical composition comprising the compound | KOWA CO., LTD. (JP) | 2006-08-24 | — | — | US | disclosed |
| EP-1661890-A1 | PPAR-ACTIVATING COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | Kowa Co., Ltd. (JP) | 2006-05-31 | — | — | EP | disclosed |
| US-20050101636-A1 | PPAR-activating compound and pharmaceutical composition comprising the compound | KOWA CO., LTD. (JP) | 2005-05-12 | — | — | US | disclosed |
| WO-2003055866-A1 | QUINAZOLINE AND QUINOLINE DERIVATIVE COMPOUNDS AS INHIBITORS OF PROLYLPEPTIDASE, INDUCERS OF APOPTOSIS AND CANCER TREATMENT AGENTS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-07-10 | — | — | WO | disclosed |
| EP-0760368-B1 | PYRIMIDINE DERIVATIVES | NISSHIN FLOUR MILLING CO (JP) | 1999-07-28 | — | — | EP | disclosed |
| US-5736550-A | TREATMENT OF GASTROINTESTINAL TRACT DISORDERS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-04-07 | — | — | US | disclosed |
| EP-0760368-A1 | NOVEL PYRIMIDINE DERIVATIVE | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-03-05 | — | — | EP | disclosed |
| EP-0183147-A2 | Beta-substituted aminophenethylazol derivatives | NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) | 1986-06-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230127965-A1 | METHODS FOR TREATING, AMELIORATING, OR PREVENTING VIRAL INFECTIONS | TMEM97, SIGMAR1, OPRL1 | MAOB 1672/4885DRD2 302/4885DRD4 1402/4885 |
| US-20060189667-A1 | PPAR-activating compound and pharmaceutical composition comprising the compound | PPARA, PPARG, PPARD | MAOB 1675/4885DRD2 863/4885DRD4 572/4885 |
| US-20200087730-A1 | METHODS OF IDENTIFYING AND TREATING TUMORS WITH SIGMA1 INHIBITORS | SIGMAR1, TMEM97, OPRK1 | MAOB 1243/4885DRD2 1041/4885DRD4 1820/4885 |
| US-10314795-B2 | Sigma receptor ligands and methods of modulating cellular protein homeostasis using same | SIGMAR1, TMEM97, ADRM1 | MAOB 2248/4885DRD2 1257/4885DRD4 1809/4885 |
| US-20180235910-A1 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | TMEM97, SIGMAR1, ADRM1 | MAOB 2353/4885DRD2 1343/4885DRD4 1754/4885 |
| US-20160361279-A1 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | TMEM97, SIGMAR1, ADRM1 | MAOB 2353/4885DRD2 1343/4885DRD4 1754/4885 |
| US-20050101636-A1 | PPAR-activating compound and pharmaceutical composition comprising the compound | PPARG, PPARA, PPARD | MAOB 4456/4885DRD2 2217/4885DRD4 2509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.