Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.64 |
| ▸ | HTR2B | P41595 | 4/20 | 0.64 |
| ▸ | HTR2A | P28223 | 4/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.64 |
| ▸ | HTR2C | P28335 | 3/20 | 0.64 |
| ▸ | HTR3A | P46098 | 2/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | CASP6 | P55212 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10123935 | 0.85 | KCNH2 (0.66) | KCNH2HTR2BHTR2ACYP3A4CYP1A2 | |
| SCHEMBL1484 | 0.82 | KCNH2 (0.62) | KCNH2HTR2BHTR2ACYP3A4CYP1A2 | |
| Maleic Acid SCHEMBL9675 | 0.81 | KCNH2 (0.60) | KCNH2HTR2BHTR2ACYP3A4CYP1A2 | |
| SCHEMBL1101 | 0.81 | KCNH2 (0.60) | KCNH2HTR2BHTR2ACYP3A4CYP1A2 | |
| Fumaric Acid SCHEMBL9676 | 0.81 | KCNH2 (0.60) | KCNH2HTR2BHTR2ACYP3A4CYP1A2 | |
| Alosetron SCHEMBL29377019 | 0.78 | KCNH2 (1.00) | KCNH2HTR2BHTR2ACYP3A4CYP1A2 | |
| Alosetron SCHEMBL631 | 0.78 | KCNH2 (1.00) | KCNH2HTR2BHTR2ACYP3A4CYP1A2 | |
| Alosetron SCHEMBL29387635 | 0.78 | CASP6 (1.00) | KCNH2HTR2BHTR2ACYP3A4CYP1A2 | |
| Alosetron SCHEMBL806 | 0.78 | CASP6 (1.00) | KCNH2HTR2BHTR2ACYP3A4CYP1A2 | |
| SCHEMBL1133 | 0.77 | KCNH2 (0.56) | KCNH2HTR2BHTR2ACYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101782-B2 | Drug hybrid of rivastigmine or physostigmine with tranylcypromine, amoxapine, desipramine, nortriptyline, protriptyline, fluoxetine, fluvoxamine, paroxetine, duloxetine, betahistine, amlodipine, proylhexedrine, rimantadine, desloratadine; Alzheimer's disease; Parkinson's disease, impairment in memory | COLUCID PHARMACEUTICALS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-20080261950-A1 | Compounds that inhibit cholinesterase | COLUCID PHARMACEUTICALS, INC. (US) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261950-A1 | Compounds that inhibit cholinesterase | ACHE, BCHE, CHAT | KCNH2 1906/4885HTR2B 1257/4885HTR2A 1087/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.