Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.43 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.43 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10102873 | 0.84 | SMN1; SMN2 (0.39) | SMN1; SMN2GNAI3GNAO1GNAI1TSHR | |
| SCHEMBL16257066 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2GNAI3GNAO1GNAI1EPHX2 | |
| SCHEMBL10108953 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2GNAI3GNAO1GNAI1EPHX2 | |
| SCHEMBL17285633 | 0.79 | GNAI3 (0.55) | SMN1; SMN2GNAI3GNAO1GNAI1ALOX15 | |
| SCHEMBL20965465 | 0.75 | SMN1; SMN2 (0.47) | SMN1; SMN2GNAI3GNAO1GNAI1EPHX2 | |
| SCHEMBL19009042 | 0.75 | SMN1; SMN2 (0.63) | SMN1; SMN2GNAI3GNAO1GNAI1EPHX2 | |
| SCHEMBL24940838 | 0.74 | GNAI3 (0.59) | SMN1; SMN2GNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL12141805 | 0.74 | HSD17B10 (0.50) | SMN1; SMN2GNAI3GNAO1GNAI1L3MBTL1 | |
| SCHEMBL13622462 | 0.73 | EPHX1 (0.55) | SMN1; SMN2EPHX2ALDH1A1LMNAACKR3 | |
| SCHEMBL26203010 | 0.71 | HSD17B10 (0.55) | SMN1; SMN2GNAI3GNAO1GNAI1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015959-A1 | HETEROCYCLIC COMPOUNDS AS AUTOTAXIN INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015959-A1 | HETEROCYCLIC COMPOUNDS AS AUTOTAXIN INHIBITORS | ENPP2, HAX1, MTX1 | SMN1; SMN2 4505/4885GNAI3 2496/4885GNAO1 1567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.