Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | HTR6 | P50406 | 4/20 | 0.36 |
| ▸ | BRD4 | O60885 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2123770 | 0.88 | PPARG (0.38) | MAPTL3MBTL1HTR6BRD4ALDH1A1 | |
| SCHEMBL2122196 | 0.86 | PIK3C3 (0.37) | MAPTRAPGEF4L3MBTL1ALDH1A1LMNA | |
| SCHEMBL16336240 | 0.82 | MAPT (0.41) | MAPTRAPGEF4L3MBTL1HTR6BRD4 | |
| SCHEMBL13003223 | 0.76 | RAPGEF4 (0.44) | MAPTRAPGEF4L3MBTL1HTR6BRD4 | |
| SCHEMBL10104096 | 0.72 | RAPGEF4 (0.39) | RAPGEF4L3MBTL1HTR6ALDH1A1MEN1 | |
| SCHEMBL4012555 | 0.71 | L3MBTL1 (0.49) | MAPTRAPGEF4L3MBTL1HTR6BRD4 | |
| SCHEMBL16056304 | 0.70 | RAPGEF4 (0.44) | RAPGEF4L3MBTL1HTR6ALDH1A1MEN1 | |
| SCHEMBL10112112 | 0.70 | HTR6 (0.37) | RAPGEF4L3MBTL1HTR6BRD4ALDH1A1 | |
| SCHEMBL2121103 | 0.70 | PIK3C3 (0.38) | MAPTRAPGEF4L3MBTL1BRD4ALDH1A1 | |
| SCHEMBL15366060 | 0.70 | RAPGEF4 (0.40) | RAPGEF4L3MBTL1HTR6BRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120101124-A1 | 1,2,4-OXADIAZOL DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS SPHINGOSINE 1-PHOSPHATE 1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2012-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101124-A1 | 1,2,4-OXADIAZOL DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS SPHINGOSINE 1-PHOSPHATE 1 RECEPTOR AGONISTS | S1PR1, S1PR3, S1PR2 | MAPT 2812/4885RAPGEF4 822/4885L3MBTL1 4809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.