Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 10/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.39 |
| ▸ | HTR1B | P28222 | 2/20 | 0.39 |
| ▸ | HTR1F | P30939 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | VEGFA | P15692 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13003407 | 0.84 | PPARG (0.43) | RAPGEF4HTR6HTR1AHTR1DHTR1B | |
| SCHEMBL15366060 | 0.76 | RAPGEF4 (0.40) | RAPGEF4HTR6CA1CA2L3MBTL1 | |
| SCHEMBL10112242 | 0.76 | MAPT (0.39) | RAPGEF4HTR6MAPTL3MBTL1CYP19A1 | |
| SCHEMBL31321849 | 0.73 | CA1 (0.42) | RAPGEF4HTR6CA1CA2L3MBTL1 | |
| SCHEMBL16337280 | 0.73 | MEN1 (0.43) | RAPGEF4HTR6MAPTCA1CA2 | |
| SCHEMBL10104096 | 0.72 | RAPGEF4 (0.39) | RAPGEF4HTR6CA1CA2L3MBTL1 | |
| SCHEMBL10112112 | 0.72 | HTR6 (0.37) | RAPGEF4HTR6HTR1AHTR1DHTR1B | |
| SCHEMBL15366137 | 0.70 | MAPT (0.44) | RAPGEF4HTR6MAPTCA1CA2 | |
| SCHEMBL18617117 | 0.70 | RAPGEF4 (0.55) | RAPGEF4HTR6CA1CA2L3MBTL1 | |
| SCHEMBL2121064 | 0.70 | ALDH1A1 (0.38) | RAPGEF4MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010145203-A1 | 1,2,4-OXADIAZOL DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS SPHINGOSINE 1-PHOSPHATE 1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2010-12-23 | — | — | WO | disclosed |