Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10112672 | 0.87 | GAA (0.38) | GAA | |
| SCHEMBL10112675 | 0.85 | ALDH1A1 (0.42) | GAAALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10112665 | 0.81 | KDM2B (0.43) | GAAALDH1A1 | |
| SCHEMBL10112664 | 0.81 | GLA (0.39) | GAA | |
| SCHEMBL10122798 | 0.80 | WDR91 (0.39) | GAA | |
| SCHEMBL10112656 | 0.76 | GAA (0.41) | GAASLC6A2SLC6A4SLC6A3SLC6A9 | |
| SCHEMBL10112661 | 0.75 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10112684 | 0.70 | CNR2 (0.42) | GAAALDH1A1 | |
| SCHEMBL31575348 | 0.67 | CHRNB2 (0.43) | GAASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL31575359 | 0.67 | CHRNB2 (0.43) | GAASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012135749-A2 | BIOMARKERS FOR PREDICTING SENSITIVITY TO CANCER TREATMENTS | GENENTECH, INC. (US) | 2012-10-04 | — | — | WO | disclosed |
| WO-2012088254-A1 | AUTOPHAGY INDUCER AND INHIBITOR COMBINATION THERAPY FOR THE TREATMENT OF NEOPLASMS | GENENTECH, INC. (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2011130654-A1 | FOX03A AS PREDICTIVE BIOMARKER FOR PI3K/AKT KINASE PATHWAY INHIBITOR EFFICACY | GENENTECH, INC. (US) | 2011-10-20 | — | — | WO | disclosed |